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Hi Arianna,
1) Yes. Please note that the method was tuned and mostly tested on MS patients.
2) These two versions of SAMSEG model WMH/ WM lesions differently and cannot be directly compared. The basic SAMSEG is not designed for accurate WMH or WM lesion estimation. Note that you can use the lesion version of SAMSEG on scans without lesions (see Fig. 6 here https://secure-web.cisco.com/1KM7GJ1i4uKDVvBOOHjfxLxbNpEbDV37ju32_ri0-iGtre9ZQKasYmqnwK6bi5vzt5-BaRS02ywgcOcI--IezHyHTAKt807vpLrXUZvO33iKmYOL0EeUkqkVhKXj38poEFY9bY4Djm69SgNrHqC2TpJRpU5OQUybXs5s7nPnXPv0ArkvG_YpXaiip_cs58dLk8TygUTgVuRtW8x9gYHo_BSTpTQs6pwsWwQ2nel-ejGeDe1nkcKTJcqBaT8vZrbLqyVpzVwZRXQDIXUhOjCyNPkbtTJdnT8BSGUjOyXcMp0Etejbfjh9bThJhaEK0tzEhXSLDLIgxCcSmrxk53keXlg/https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS1053811920309563).
3) Yes. Note that SWI data might not add valuable information to the lesion and whole-brain segmentation task. My suggestion is to visually inspect a couple of subjects with and without SWI data.
Stefano
Sent on behalf of Arianna Menardi:
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Dear Experts,
I'm trying to quantify the volume of some white matter lesions in an elderly group. I have tried using both Samseg cross-sectional, as well as Samseg for MS lesions.
I am new to the approach so I have 3 main questions: 1. Can I use Samseg for MS lesions even if my patients present WM lesions but are not MS patients? 2. the estimated values of WM-hypointensities derived from the basic version of Samseg are almost half in size compared to the output 'Lesions" of Samseg specific for MS lesions. What is hence the difference between the two approaches that could explain such a big difference in the output? 3. Can I use Samseg combining T1w, FLAIR and SWI data? Or the algorithms are not suited for SWI images?
Thank you for your help, Arianna
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