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Dear community,
I tried to process MS- patient's MRIs (mostly same scanner, same settings) Longitudinally over a long period of time. I first processed all timeponits crosssectionally and then initialised the base image by recon- all - base TP1 TP2 TP3 etc. Now I am trying to run label based morphometry and it seems some areas are growing rather than shrinking. Which is highly unlikely. I tried to exclude timepoint of a relapse to rule out perifocal edema interfering with measures but the problem remains. Did anybody have the same problem? Is it a potential bug or just a garbage in garbage out problem (though I don't know what would be wrong with our scans)? Does it make sense to make an intermediate template for two timeponits only? I.e. recon- all -base TP1 TP2; recon -all -base TP2 TP3 ... and use them for longitudinal runs?
Thanks for your opinions. Best Matthias