Dear Freesurfer experts,
I am interested in a specific brain region that is based on the 2009 atlas. I used Qdec to 'Generate Stats Data Tables' to get the cortical thickness info for this region and saved them in a file. Then I used SPSS and did an ANOVA test. The ANOVA test reveals that the patient group (versus the neurotypical group) has significantly cortical thinning in this region (p < .05). I am also able to see this significant effect in this region using 'Display' in Qdec. However, once I hit 'FDR' button (q = .05), the minimum t-value associated with significant data increased from around 2 to more than 4. And the significant effect in this region does not survive FDR, as seen in the Display.
My questions:
1. Is what I did the usual procedure to do FDR correction? How do I see the significance value of this region under FDR (q=.05)? 2. Is the normal that the minimum t-value increased so much when doing FDR? 3. Do I have to do FDR since I'm only interested in a very specific region?
Thank you! Daniel