why would one control for total brain volume in doing vertex-based
analyses when the vertex-based measures are computed in standard space?
The vertex-based measures are computed in individual space, not standard space doug
Dear Doug,
I would like to know at what stage the measures computed in individual space are normalised, if at all, in order to make comparisons of data across participants (e.g. in qdec) meaningful. Differences in the relative position of a particular structure across participants will make it difficult if not impossible to examine effects at the group level. If the vertex-wise data is in individual space, then I’m not sure that I understand how using total brain volume as a covariate would solve the above problem. I would greatly appreciate any clarifications that you might have.
Best wishes, Narly.