This is a known issue. See https://surfer.nmr.mgh.harvard.edu/fswiki/ReleaseNotes
Known Issues: The global morphometry statistics embedded in aseg.stats and other files have an error when the input volume has a voxel resolution different than 1mm^3.
Check and see if this is what you are encountering
On 8/19/2021 11:53 AM, Petersen, Marvin wrote:
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Dear FreeSurfer Team,
we use smriprep for structural preprocessing and surface reconstruction on our local HPC. It contains freesurfer-Linux-centos6_x86_64-stable-pub-v6.0.1-f53a55a.
The image outputs look flawless. However, BrainSeg and BrainSegNotVent reported in aseg.stats are far above expected values (for instance larger than eTIV; example output attached).
We have processed 600 subjects and the issue applies to all of them. We are currently trying to reproduce these results with freesurfer on a local machine to make sure it's not flawed data or smriprep that is responsible for the issue.
As computing brain volume by hand with aseg.mgz yields sensible results (~1.3 mio mm³) we consider mri_segstats in smriprep to be the problem.
Grateful for any input.
Cheers, Marvin
# Title Segmentation Statistics # # generating_program mri_segstats # cvs_version $Id: mri_segstats.c,v 1.121 2016/05/31 17:27:11 greve Exp $ # cmdline mri_segstats --seg mri/aseg.mgz --sum stats/aseg.stats --pv mri/norm.mgz --empty --brainmask mri/brainmask.mgz --brain-vol-from-seg --excludeid 0 --excl-ctxgmwm --supratent --subcortgray --in mri/norm.mgz --in-intensity-name norm --in-intensity-units MR --etiv --surf-wm-vol --surf-ctx-vol --totalgray --euler --ctab /work/fatx405/local/freesurfer-6.0.0/ASegStatsLUT.txt --subject sub-003db57e # sysname Linux # hostname node001 # machine x86_64 # user fatx405 # anatomy_type volume # # SUBJECTS_DIR /work/fatx405/projects # subjectname sub-003db57e # Measure BrainSeg, BrainSegVol, Brain Segmentation Volume, 2142619.000000, mm^3 # Measure BrainSegNotVent, BrainSegVolNotVent, Brain Segmentation Volume Without Ventricles, 2096581.000000, mm^3 # Measure BrainSegNotVentSurf, BrainSegVolNotVentSurf, Brain Segmentation Volume Without Ventricles from Surf, 1306062.635541, mm^3 # Measure VentricleChoroidVol, VentricleChoroidVol, Volume of ventricles and choroid plexus, 39720.000000, mm^3 # Measure lhCortex, lhCortexVol, Left hemisphere cortical gray matter volume, 243502.815347, mm^3 # Measure rhCortex, rhCortexVol, Right hemisphere cortical gray matter volume, 247635.016739, mm^3 # Measure Cortex, CortexVol, Total cortical gray matter volume, 491137.832086, mm^3 # Measure lhCerebralWhiteMatter, lhCerebralWhiteMatterVol, Left hemisphere cerebral white matter volume, 229977.705303, mm^3 # Measure rhCerebralWhiteMatter, rhCerebralWhiteMatterVol, Right hemisphere cerebral white matter volume, 231861.098152, mm^3 # Measure CerebralWhiteMatter, CerebralWhiteMatterVol, Total cerebral white matter volume, 461838.803455, mm^3 # Measure SubCortGray, SubCortGrayVol, Subcortical gray matter volume, 97441.000000, mm^3 # Measure TotalGray, TotalGrayVol, Total gray matter volume, 789956.832086, mm^3 # Measure SupraTentorial, SupraTentorialVol, Supratentorial volume, 1083680.635541, mm^3 # Measure SupraTentorialNotVent, SupraTentorialVolNotVent, Supratentorial volume, 1043960.635541, mm^3 # Measure SupraTentorialNotVentVox, SupraTentorialVolNotVentVox, Supratentorial volume voxel count, 1840953.000000, mm^3 # Measure Mask, MaskVol, Mask Volume, 2714626.000000, mm^3 # Measure BrainSegVol-to-eTIV, BrainSegVol-to-eTIV, Ratio of BrainSegVol to eTIV, 1.272865, unitless # Measure MaskVol-to-eTIV, MaskVol-to-eTIV, Ratio of MaskVol to eTIV, 1.612677, unitless # Measure lhSurfaceHoles, lhSurfaceHoles, Number of defect holes in lh surfaces prior to fixing, 37, unitless # Measure rhSurfaceHoles, rhSurfaceHoles, Number of defect holes in rh surfaces prior to fixing, 25, unitless # Measure SurfaceHoles, SurfaceHoles, Total number of defect holes in surfaces prior to fixing, 62, unitless # Measure EstimatedTotalIntraCranialVol, eTIV, Estimated Total Intracranial Volume, 1683304.717707, mm^3 # SegVolFile mri/aseg.mgz # SegVolFileTimeStamp 2021/08/19 16:13:35 # ColorTable /work/fatx405/local/freesurfer-6.0.0/ASegStatsLUT.txt # ColorTableTimeStamp 2018/08/13 14:53:06 # InVolFile mri/norm.mgz # InVolFileTimeStamp 2021/08/19 16:13:32 # InVolFrame 0 # PVVolFile mri/norm.mgz # PVVolFileTimeStamp 2021/08/19 16:13:32 # Excluding Cortical Gray and White Matter # ExcludeSegId 0 2 3 41 42 # VoxelVolume_mm3 0.578704 # TableCol 1 ColHeader Index # TableCol 1 FieldName Index # TableCol 1 Units NA # TableCol 2 ColHeader SegId # TableCol 2 FieldName Segmentation Id # TableCol 2 Units NA # TableCol 3 ColHeader NVoxels # TableCol 3 FieldName Number of Voxels # TableCol 3 Units unitless # TableCol 4 ColHeader Volume_mm3 # TableCol 4 FieldName Volume # TableCol 4 Units mm^3 # TableCol 5 ColHeader StructName # TableCol 5 FieldName Structure Name # TableCol 5 Units NA # TableCol 6 ColHeader normMean # TableCol 6 FieldName Intensity normMean # TableCol 6 Units MR # TableCol 7 ColHeader normStdDev # TableCol 7 FieldName Itensity normStdDev # TableCol 7 Units MR # TableCol 8 ColHeader normMin # TableCol 8 FieldName Intensity normMin # TableCol 8 Units MR # TableCol 9 ColHeader normMax # TableCol 9 FieldName Intensity normMax # TableCol 9 Units MR # TableCol 10 ColHeader normRange # TableCol 10 FieldName Intensity normRange # TableCol 10 Units MR # NRows 45 # NTableCols 10 # ColHeaders Index SegId NVoxels Volume_mm3 StructName normMean normStdDev normMin normMax normRange 1 4 20298 11994.6 Left-Lateral-Ventricle 27.8315 11.9737 11.0000 93.0000 82.0000 2 5 500 344.7 Left-Inf-Lat-Vent 45.6800 12.3120 15.0000 78.0000 63.0000 3 7 27409 16402.5 Left-Cerebellum-White-Matter 82.5499 5.4997 37.0000 97.0000 60.0000 4 8 96661 55934.2 Left-Cerebellum-Cortex 62.4935 9.7135 0.0000 133.0000 133.0000 5 10 13493 7617.2 Left-Thalamus-Proper 90.8387 9.8593 30.0000 114.0000 84.0000 6 11 5022 2935.7 Left-Caudate 83.4389 8.1582 38.0000 107.0000 69.0000 7 12 7212 4143.9 Left-Putamen 91.5836 7.3237 47.0000 109.0000 62.0000 8 13 3570 2071.3 Left-Pallidum 103.8275 4.9761 56.0000 119.0000 63.0000 9 14 2192 1353.2 3rd-Ventricle 32.0027 11.5672 15.0000 79.0000 64.0000 10 15 1986 1251.9 4th-Ventricle 35.6591 12.4108 12.0000 76.0000 64.0000 11 16 41250 24051.8 Brain-Stem 81.4896 9.2479 22.0000 111.0000 89.0000 12 17 7369 4120.0 Left-Hippocampus 72.6194 8.3441 33.0000 106.0000 73.0000 13 18 3042 1695.2 Left-Amygdala 71.5999 6.1066 37.0000 99.0000 62.0000 14 24 2140 1185.9 CSF 43.4280 13.4853 16.0000 89.0000 73.0000 15 26 666 384.1 Left-Accumbens-area 78.7327 4.1748 55.0000 92.0000 37.0000 16 28 7719 4298.9 Left-VentralDC 91.9097 10.6368 29.0000 121.0000 92.0000 17 30 181 126.6 Left-vessel 54.9834 12.0437 28.0000 77.0000 49.0000 18 31 1531 819.7 Left-choroid-plexus 49.5532 11.3961 22.0000 81.0000 59.0000 19 43 15549 9136.9 Right-Lateral-Ventricle 29.6998 13.2484 9.0000 94.0000 85.0000 20 44 403 267.4 Right-Inf-Lat-Vent 45.0025 12.8842 16.0000 80.0000 64.0000 21 46 26601 15867.2 Right-Cerebellum-White-Matter 82.2607 5.5614 35.0000 97.0000 62.0000 22 47 99608 57495.8 Right-Cerebellum-Cortex 62.0247 9.5405 17.0000 106.0000 89.0000 23 49 13412 7495.8 Right-Thalamus-Proper 87.9864 9.8004 31.0000 110.0000 79.0000 24 50 5187 3006.0 Right-Caudate 81.9400 8.5023 44.0000 105.0000 61.0000 25 51 7601 4339.7 Right-Putamen 89.1673 7.5487 44.0000 109.0000 65.0000 26 52 3692 2139.9 Right-Pallidum 102.9976 4.7986 61.0000 117.0000 56.0000 27 53 7445 4205.5 Right-Hippocampus 71.2660 7.9302 27.0000 99.0000 72.0000 28 54 3503 1970.0 Right-Amygdala 71.8310 5.9510 43.0000 100.0000 57.0000 29 58 849 475.8 Right-Accumbens-area 79.5324 5.1089 62.0000 99.0000 37.0000 30 60 7709 4301.8 Right-VentralDC 91.0214 11.1633 24.0000 117.0000 93.0000 31 62 76 55.6 Right-vessel 55.0132 13.2991 26.0000 75.0000 49.0000 32 63 1439 795.1 Right-choroid-plexus 48.4830 10.2814 17.0000 78.0000 61.0000 33 72 0 0.0 5th-Ventricle 0.0000 0.0000 0.0000 0.0000 0.0000 34 77 2497 1370.8 WM-hypointensities 73.4529 12.6269 14.0000 113.0000 99.0000 35 78 0 0.0 Left-WM-hypointensities 0.0000 0.0000 0.0000 0.0000 0.0000 36 79 0 0.0 Right-WM-hypointensities 0.0000 0.0000 0.0000 0.0000 0.0000 37 80 0 0.0 non-WM-hypointensities 0.0000 0.0000 0.0000 0.0000 0.0000 38 81 0 0.0 Left-non-WM-hypointensities 0.0000 0.0000 0.0000 0.0000 0.0000 39 82 0 0.0 Right-non-WM-hypointensities 0.0000 0.0000 0.0000 0.0000 0.0000 40 85 248 153.8 Optic-Chiasm 78.9476 17.7778 26.0000 115.0000 89.0000 41 251 1428 779.4 CC_Posterior 101.7458 17.1102 32.0000 121.0000 89.0000 42 252 734 379.2 CC_Mid_Posterior 93.2657 16.0395 36.0000 114.0000 78.0000 43 253 759 388.9 CC_Central 93.6245 16.6766 41.0000 113.0000 72.0000 44 254 785 422.7 CC_Mid_Anterior 100.7949 14.9042 47.0000 116.0000 69.0000 45 255 1539 836.8 CC_Anterior 100.6595 16.0710 32.0000 121.0000 89.0000
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