[Freesurfer] Question regarding General Linear Model analysis with Freesurfer

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Hi!

I hope you are doing well!

I am working on a paper where we used Freesurfer for whole brain analysis in intergroup comparison (g2v1). The objective of the analysis is to see if there is an association between neuropsychiatric symptoms and brain regions at different stages of Alzheimer's disease (Alzheimer, Mild cognitive impairment and cognitively normal participants).

For this objective, a whole-brain analysis was performed using general linear model (GLM) analysis with FreeSurfer mri_glmfit for each neuropsychiatric symptoms of interest to assess their effect on brain’s cortical volume, thickness and area, between the groups (AD vs MCI, CN vs MCI, CN vs AD). We performed a Monte-Carlo correction on the results obtained.

I was wondering if it was possible to add another correction for multiple group comparison in addition to the Monte-Carlo correction?

Also, is it possible to add covariates by creating additional models using the GLM analysis with Freesurfer mri_glmfit?

Thank you in advance! Lyna El Haffaf

Graduate student in neuropsychology

Université de Montréal