[Freesurfer] analyses of single trials

Hi, Is it possible, with existing software, to extract signal changes at vertices, voxels, or ROIs for single trials, rather than across trials? This would allow an examination of intra-subject variability in BOLD response, habituation effects, etc... Something like this was done by: Yamaguchi S, Hale LA, D'Esposito M, Knight RT (2004): Rapid prefrontal-hippocampal habituation to novel events. J Neurosci 24:5356-5363. thanks, Dara

Dara S. Manoach, Ph.D. Psychiatric Neuroimaging Massachusetts General Hospital Charlestown Navy Yard 149 13th Street, Room 2608 Charlestown, MA 02129 email: dara@nmr.mgh.harvard.edu phone: 617-724-6148 fax: 617-726-4078

http://nmr.mgh.harvard.edu/manoachlab