[Freesurfer] SAMSEG longitudinal processing questions

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Hi FreeSurfers,

Thank you for sharing the new SAMSEG tool, which I consider a major breakthrough in image processing! I have a few questions about using SAMSEG vs SAMSEG_Long:

1. What volumetric differences should I expect between running SAMSEG on individual images, vs. using SAMSEG_Long for the longitudinal analysis? Could I use SBTIV to adjust differences between scans? (all images are FLAIRs preprocessed using mrI_robust_template)

2. Is there currently a way to integrate lesion segmentation into the SAMSEG_long’s longitudinal analysis?

3. What is the expected impact of increasing or decreasing -Burn-In and -Sample numbers for lesion segmentation?

Thank you for all the help!

Best,

Dave Kamson