External Email - Use Caution
I found it hard to read the quoted mails and to follow along, but if I'm not mistaken you are trying to overlay a self-created mgh file with dimension 10242x1x1 onto the pial surface of sub-002 at sub-002/surf/lh.pial.
How many vertices does sub-002/surf/lh.pial have? If the answer is not 10242, this is not gonna work.
In one of the earlier mails you mentioned fsaverage5. Could it it be that you really intend to overlay onto $FREESURFER_HOME/subjects/fsaverage5/surf/lh.pial?
Best,
Tim
On June 26, 2019 at 10:48 AM Loïc Daumail loic.daumail@gmail.com wrote:
External Email - Use CautionHi Freesurfer, Getting back the former request, I am still trying to load an overlay of my data onto a surface.. but it still doesn't work well. Here is the info of my overlay: " mri_info lh_emb_comp_sub-002.mgz Volume information for lh_emb_comp_sub-002.mgz type: MGH dimensions: 10242 x 1 x 1 voxel sizes: 1.000000, 1.000000, 1.000000 type: FLOAT (3) fov: 10242.000 dof: 1 xstart: -5121.0, xend: 5121.0 ystart: -0.5, yend: 0.5 zstart: -0.5, zend: 0.5 TR: 0.00 msec, TE: 0.00 msec, TI: 0.00 msec, flip angle: 0.00 degrees nframes: 1 PhEncDir: UNKNOWN FieldStrength: 0.000000 ras xform present xform info: x_r = -1.0000, y_r = 0.0000, z_r = 0.0000, c_r = 0.0000 : x_a = 0.0000, y_a = 0.0000, z_a = 1.0000, c_a = 0.0000 : x_s = 0.0000, y_s = -1.0000, z_s = 0.0000, c_s = 0.0000
talairach xfm : Orientation : LIA Primary Slice Direction: coronal
voxel to ras transform: -1.0000 0.0000 0.0000 5121.0000 0.0000 0.0000 1.0000 -0.5000 0.0000 -1.0000 0.0000 0.5000 0.0000 0.0000 0.0000 1.0000
voxel-to-ras determinant -1
ras to voxel transform: -1.0000 -0.0000 -0.0000 5121.0000 -0.0000 -0.0000 -1.0000 0.5000 -0.0000 1.0000 -0.0000 0.5000 -0.0000 -0.0000 -0.0000 1.0000 " Here is what I get when loading on freeview:
" freeview -f ~/Documents/recon_all_success/freesurfer/sub-002/surf/lh.pial:overlay=lh_emb_comp_sub-002.mgz Number of vertices in overlay data does not match with surface. QClipboard: Unable to receive an event from the clipboard manager in a reasonable time " The data was normalized in MNI space. When I try to load it in FSLeyes, it works, but the overlay is completely absent, it seems that it's empty. On the FSLeyes GUI, it's written 'overlay out of bounds'... The endpoint of this process would be to define ROIs in specific regions, and Freeview is very handy with atlases. Any advice is welcome!
Thanks in advance,
Sincerely,
Loïc
Le lun. 24 juin 2019 à 17:01, Loïc Daumail loic.daumail@gmail.com a écrit :
I also tried saving the last file in 10242 x 1 x 1.. but nothing is coming neither.
Thanks,
Sincerely,
Loïc
Le lun. 24 juin 2019 à 16:50, Loïc Daumail loic.daumail@gmail.com a écrit :
Hi Doug,
Thanks for your help!
However, using mri_convert, I still get the same message with tclsh. " mri_convert lh.thickness template.mgh /usr/share/modules/init/bash: line 36: /usr/bin/tclsh: No such file or directory /usr/share/modules/init/bash: line 58: export: _moduleraw: not a function /usr/share/modules/init/bash: line 60: export: module: not a function mri_convert.bin lh.thickness template.mgh $Id: mri_convert.c,v 1.226 2016/02/26 16:15:24 mreuter Exp $ reading from lh.thickness... TR=0.00, TE=0.00, TI=0.00, flip angle=0.00 i_ras = (-1, 0, 0) j_ras = (0, 0, -1) k_ras = (0, 1, 0) writing to template.mgh... " There is progess though, as here, we see that template.mgh seems not empty: " mri_info template.mgh Volume information for template.mgh type: MGH dimensions: 10242 x 1 x 1 voxel sizes: 1.000000, 1.000000, 1.000000 type: FLOAT (3) fov: 10242.000 dof: 0 xstart: -5121.0, xend: 5121.0 ystart: -0.5, yend: 0.5 zstart: -0.5, zend: 0.5 TR: 0.00 msec, TE: 0.00 msec, TI: 0.00 msec, flip angle: 0.00 degrees nframes: 1 PhEncDir: UNKNOWN FieldStrength: 0.000000 ras xform present xform info: x_r = -1.0000, y_r = 0.0000, z_r = 0.0000, c_r = 0.0000 : x_a = 0.0000, y_a = 0.0000, z_a = 1.0000, c_a = 0.0000 : x_s = 0.0000, y_s = -1.0000, z_s = 0.0000, c_s = 0.0000
talairach xfm : Orientation : LIA Primary Slice Direction: coronal
voxel to ras transform: -1.0000 0.0000 0.0000 5121.0000 0.0000 0.0000 1.0000 -0.5000 0.0000 -1.0000 0.0000 0.5000 0.0000 0.0000 0.0000 1.0000
voxel-to-ras determinant -1
ras to voxel transform: -1.0000 -0.0000 -0.0000 5121.0000 -0.0000 -0.0000 -1.0000 0.5000 -0.0000 1.0000 -0.0000 0.5000 -0.0000 -0.0000 -0.0000 1.0000 " Also, using MRIread and MRIwrite, we can see that it's not empty neither:
" Volume information for lh_emb_comp_sub-002.mgz type: MGH dimensions: 1 x 10242 x 1 voxel sizes: 1.000000, 1.000000, 1.000000 type: FLOAT (3) fov: 10242.000 dof: 1 xstart: -0.5, xend: 0.5 ystart: -5121.0, yend: 5121.0 zstart: -0.5, zend: 0.5 TR: 0.00 msec, TE: 0.00 msec, TI: 0.00 msec, flip angle: 0.00 degrees nframes: 1 PhEncDir: UNKNOWN FieldStrength: 0.000000 ras xform present xform info: x_r = -1.0000, y_r = 0.0000, z_r = 0.0000, c_r = 5120.5000 : x_a = 0.0000, y_a = 0.0000, z_a = 1.0000, c_a = 0.0000 : x_s = 0.0000, y_s = -1.0000, z_s = 0.0000, c_s = -5120.5000
talairach xfm : Orientation : LIA Primary Slice Direction: coronal
voxel to ras transform: -1.0000 0.0000 0.0000 5121.0000 0.0000 0.0000 1.0000 -0.5000 0.0000 -1.0000 0.0000 0.5000 0.0000 0.0000 0.0000 1.0000
voxel-to-ras determinant -1
ras to voxel transform: -1.0000 -0.0000 -0.0000 5121.0000 -0.0000 -0.0000 -1.0000 0.5000 -0.0000 1.0000 -0.0000 0.5000 -0.0000 -0.0000 -0.0000 1.0000 "
But then, trying to load the overlay on the lh.pial still isn't possible, with endless "FreadFloat: fread failed"
Thanks in advance for your help,
Sincerely,
Loïc
Le lun. 24 juin 2019 à 14:21, Greve, Douglas N.,Ph.D. < DGREVE@mgh.harvard.edu> a écrit :
It is probably using a tcsh shell to do the compression. Try using MRIwrite instead. You will have to create an mri structure. The easiest way to do that is to mri_convert lh.thickness template.mgh then read the template in to matlab template = MRIread('template.mgh'); template.vol = yourdata MRIwrite(template,'yourdata.mgz')
On 6/24/2019 11:54 AM, Loïc Daumail wrote:
External Email - Use CautionHi Bruce and Doug,
To respond to your questions: I projected the BOLD data on the surface using mri_vol2surf function. Then obtained a .mgz file of size 10242 x 1 x 1 x 200.
Then I performed diffusion embedding (unsupervised dimensionality reduction technique) on this .mgz file, whose output was a .npy file. I then loaded this file into a matrix on python, which size was 1 x 18715 x 5. I then saved this file as a .mat file. Then loaded it on matlab, and kept only 1 x 18715 x 1 part of the matrix, and stored it into a zeros(1, 20484). Then kept only the part from (0:10242) and used save_mgh function to save this data into a .mgz file Looking at the info of my .mgz file created with save_mgh, I see that the file doesn't seem to include the data:
" mri_info lh_emb_sub-002_compassion.mgz Volume information for lh_emb_sub-002_compassion.mgz type: MGH dimensions: 1 x 16 x 1 voxel sizes: -nan, -nan, -nan type: FLOAT (3) fov: -nan dof: 1 xstart: -nan, xend: -nan ystart: -nan, yend: -nan zstart: -nan, zend: -nan TR: 0.00 msec, TE: 0.00 msec, TI: 0.00 msec, flip angle: 0.00 degrees nframes: 1 PhEncDir: UNKNOWN FieldStrength: 0.000000 ras xform present xform info: x_r = -nan, y_r = -nan, z_r = -nan, c_r = -nan : x_a = -nan, y_a = -nan, z_a = -nan, c_a = -nan : x_s = -nan, y_s = -nan, z_s = -nan, c_s = -nan
talairach xfm : Orientation : III Primary Slice Direction: axial
voxel to ras transform: -nan -nan -nan -nan -nan -nan -nan -nan -nan -nan -nan -nan 0.0000 0.0000 0.0000 1.0000
voxel-to-ras determinant -nan
ras to voxel transform: mat = NULL! MatrixFree: NULL mat POINTER! " It seems that save_mgh function requires tclsh package, as when I ran save_mgh for the first time with this command line: save_mgh('freeview_overlay', ['/home/loic/Documents/emb_output/mgh_format/emb_' char(subjectsList(1)) '_' char(statesList(1)) '.MGZ'], M);
I was getting this message in return in the matlab window: " /usr/share/modules/init/bash: line 36: /usr/bin/tclsh: No such file or directory /usr/share/modules/init/bash: line 58: export: _moduleraw: not a function /usr/share/modules/init/bash: line 60: export: module: not a function " Checking into the '/usr/bin/tclsh' directory, the only package called/related to tclsh was 'tclsh8.6'. I thus changed the name from 'tclsh8.6' to 'tclsh'.
Then tried to save the matrix again with save_mgh function. Now I don't see the error message anymore. However I still get a .mgz file with nans, as seen in the previous mri_info message above.
Would any of you have an advice on how I could make this work, in order to visualize this .mgz file on the left hemisphere pial surface in Freeview?
Thanks in advance,
Sincerely,
Loïc
Le ven. 21 juin 2019 à 16:24, Bruce Fischl fischl@nmr.mgh.harvard.edu a écrit :
I don't think it matters but I would use eye instead of nan for M. But the critical issue is where you get your data and what dimensions it has cheers Bruce
On Fri, 21 Jun 2019, Loïc Daumail wrote:
External Email - Use CautionMe again,
Also, here is how I save the matrix on matlab:
M = nan(4,4); save_mgh('freeview_overlay',
['/home/loic/Documents/emb_output/mgh_format/lh_emb_'
char(subjectsList(1)) '_' char(statesList(1)) '.mgz'], M);
Thanks,
Sincerely,
Loïc
Le ven. 21 juin 2019 à 12:25, Loïc Daumail loic.daumail@gmail.com
a écrit :
Hi Bruce,Thanks for your tip. Unfortunately, I am still running through an
error...
I have a matrix of 18715 elements regarding both hemispheres. The size of fsaverage5 is 20484 I believe, so I filled the remaining
elements with zeros, and
also tried with rand().
The other issue is that I am not so sure which part of the matrix is
for lh and the other one
for rh. Thus, I divided 18715/2 and took the 9357 first elements of
the 18715 matrix. Then
filled it with zeros or random values to reach 10242.
Then I saved it with save_mgh function and tried to load it with
freeview using the following
command line: freeview
-f~/Documents/recon_all_success/freesurfer/fsaverage5/surf/lh.pial:overlay=~/Documents/emb_output/mgh
_format/lh_emb_sub-002_compassion.mgz
I am getting the following error: " Did not find any volume info 2 [0]PETSC ERROR:
[0]PETSC ERROR: Caught signal number 11 SEGV: Segmentation Violation,
probably memory access
out of range [0]PETSC ERROR: Try option -start_in_debugger or
-on_error_attach_debugger
[0]PETSC ERROR: or see
http://www.mcs.anl.gov/petsc/petsc-as/documentation/troubleshooting.html#Sig... ERROR:
or try http://valgrind.org on linux or man libgmalloc on Apple to
find memory corruption
errors [0]PETSC ERROR: configure using --with-debugging=yes, recompile,
link, and run
[0]PETSC ERROR: to get more information on the crash. [0]PETSC ERROR: --------------------- Error Message
[0]PETSC ERROR: Signal received! [0]PETSC ERROR:
[0]PETSC ERROR: Petsc Release Version 2.3.3, Patch 13, Thu May 15
17:29:26 CDT 2008 HG
revision: 4466c6289a0922df26e20626fd4a0b4dd03c8124 [0]PETSC ERROR: See docs/changes/index.html for recent updates. [0]PETSC ERROR: See docs/faq.html for hints about trouble shooting. [0]PETSC ERROR: See docs/index.html for manual pages. [0]PETSC ERROR:
[0]PETSC ERROR: Unknown Name on a linux-gnu named loic-HP-ZBook-17 by
loic Fri Jun 21 12:15:53
2019 [0]PETSC ERROR: Libraries linked
from/autofs/space/lyon_006/pubsw/Linux2-2.3-x86_64/packages/petsc/2.3.3-p13/src/petsc-2.3.3-p13/lib/lin
ux-gnu-c-opt [0]PETSC ERROR: Configure run at Tue Aug 10 15:01:59 2010 [0]PETSC ERROR: Configure options --with-debugging=no --with-cc=gcc
--with-fc=g77
--download-f-blas-lapack=0 --download-mpich=1 --with-mpi=1 --with-x=0 --with-gnu-copyright-code=0 --with-shared=0 COPTFLAGS=-O3
CXXOPTFLAGS=-O3 FOPTFLAGS=-O3
[0]PETSC ERROR:
[0]PETSC ERROR: User provided function() line 0 in unknown directory
unknown file
[unset]: aborting job: application called MPI_Abort(MPI_COMM_WORLD, 59) - process 0"
Any idea of what could be wrong in my process?
Thanks
Sincerely,
Loïc
Le jeu. 20 juin 2019 à 19:39, Bruce Fischl <
fischl@nmr.mgh.harvard.edu> a écrit :
Hi Loïc the .mgz file should having dimensions nvertices x 1 x 1 forfreeview to
know it is a surface overlay I believe cheers Bruce On Thu, 20 Jun 2019, Loïc Daumail wrote: > > External Email - Use Caution > > Hi Bruce, > > I am reaching out to you, as I am trying to load the surfacescalar values of
diffusion embedding > for overlay on a pial surface in Freeview. > > I used save_mgh to save a scalar matrix containing surfaceembedding values in
an .mgz format. > However I can't load it in freeview, be either only half ofthe matrix data (one
hemisphere I > assume) or the whole matrix saved in the same file. > > Is there anything specific I need to do in order to be ableto visualize a
scalar overlay on a > surface? Is .mgz a wrong format for scalar values? I alsotried with .nii.gz, or
.mgh. I am not even > sure save_mgh can do all this... > > Thanks in advance, > > Sincerely, > > Loïc > > > > Le lun. 27 mai 2019 à 11:54, Loïc Daumail <loic.daumail@gmail.com> a écrit :
> Hi Tim, > > Your link works perfectly, it's awesome! > Thanks a lot, > > Best, > > Loïc > > Le lun. 27 mai 2019 à 11:43, Loïc Daumail <loic.daumail@gmail.com> a écrit :
> Hi Tim, > > 'mean_rest' is a diffusion embedding map, which containsscores for every vertex
on > fsaverage5 surface resolution. > 'surf.b' is the pial surface of both hemispheres offsaverage5... I also tried
forjust > lh hemisphere, but it gives me the same result... > > Thanks for the link! > > Best, > > Loïc > > Le lun. 27 mai 2019 à 11:20, Tim Schäfer <ts+ml@rcmd.org> aécrit :
> External Email - Use Caution > > Hi Loïc, > > that does not look correct, the data is definitely off.I'm not sure where
> the variables `mean_rest` and `surf.b` come from inyour code, and I
suspect > that something is wrong with them. > > In the meantime, I got interested in this myself andput together some
code > that will load the Desikan data for both hemispheresand display it in
> surfstat. Feel free to use it, there also is an examplescreenshot of the
> results: > > >https://github.com/dfsp-spirit/comp_neuro_science/tree/master/surfstat_desik...
> > Best, > > Tim > > -- > Dr. Tim Schäfer > Postdoc Computational Neuroimaging > Department of Child and Adolescent Psychiatry,Psychosomatics and
> Psychotherapy > University Hospital Frankfurt, Goethe UniversityFrankfurt am Main,
Germany > > > On May 27, 2019 at 11:01 AM Loïc Daumail <loic.daumail@gmail.com> wrote:
> > > > > > External Email - Use Caution > > > > Hi Tim, > > > > Thanks a lot for your help, indeed, this is exactlywhat I needed!
> > I wrote this : > > " > > subjects_dir ='/home/loic/Documents/recon_all_success/freesurfer/';
> > subject_id = 'sub-004'; > > hemi = 'lh'; > > > > aparc_file_this_hemi = fullfile(subjects_dir,subject_id, 'label',
> > sprintf("%s.aparc.annot", hemi)); > > [vertices, label, colortable] =read_annotation(aparc_file_this_hemi);
> > fprintf("Read aparc parcellation file '%s' containing%d regions.\n",
> > aparc_file_this_hemi,length(colortable.struct_names));
> > for sidx = 1:length(colortable.struct_names) > > region = colortable.struct_names{sidx}; > > struct_code = colortable.table(sidx, 5); > > vertices_of_struct_roi = find(label ==struct_code);
> > fprintf("Found region '%s' with %d verts.\n",region,
> > length(vertices_of_struct_roi)); > > end > > fig1 = figure(); > > SurfStatView(mean_rest, surf.b); > > SurfStatColormap(colortable.table(:,1:3)/255); > > " > > However, the image I obtain seems a bit fuzzy...( seeattached)
> > Is it because of my data? > > > > Thanks in advance, > > > > Loïc > > > > > > Le jeu. 23 mai 2019 à 17:20, Tim Schäfer <ts+ml@rcmd.org> a écrit :
> > > > > External Email - Use Caution > > > > > > Afaik SurfStat is not maintained anymore and Ithink it's been this
way > > > for quite a while now. Maybe someone else knowsbetter?
> > > > > > The website is athttp://www.math.mcgill.ca/keith/surfstat/ and it
says > > > 'Updated 26 September 2008'. I'm not sure whetherthat's really true,
> but > > > at least for the last 14 months (the only timeframe I know about),
> there > > > have not been any changes to that website or anynew releases of
> SurfStat. > > > > > > Tim > > > > > > > On May 23, 2019 at 4:36 PM Bruce Fischl <fischl@nmr.mgh.harvard.edu>
> > > wrote: > > > > > > > > > > > > Hi Loic > > > > > > > > sorry, can you ask whoever maintains surfstat? Ormaybe someone else
> on > > > the > > > > list knows? I don't. You can label surfacesmanually with the dev
> > > version > > > > of freeview if you want. > > > > > > > > cheers > > > > Bruce > > > > > > > > > > > > On Thu, 23 May 2019, Loïc > > > > Daumail wrote: > > > > > > > > > > > > > > External Email - Use Caution > > > > > > > > > > Hi Bruce, > > > > > > > > > > I am coming back to this request as I waswondering:
> > > > > would it be possible to load freesurfer surfaceatlases in
surfstat > in > > > order to label my surfaces? > > > > > Is their format compatible? I saw surfstat onlyaccepts a limited
> > > array of formats... > > > > > > > > > > Thanks, > > > > > Best, > > > > > > > > > > Loïc > > > > > > > > > > Le lun. 20 mai 2019 à 16:15, Bruce Fischl > <fischl@nmr.mgh.harvard.edu> > > > a écrit : > > > > > sure. All the fsaverages are in the samespace (they are
> subsets > > > of > > > > > fsaverage) > > > > > On Mon, 20 May 2019, Loïc Daumail wrote: > > > > > > > > > > > > > > > > > External Email - Use Caution > > > > > > > > > > > > Hi Bruce, > > > > > > > > > > > > Thanks for your response. Is it alsofine for fsaverage5
> > > surface or I need to switch > > > > > my data to > > > > > > fsaverage? > > > > > > > > > > > > Thanks, > > > > > > > > > > > > Sincerely, > > > > > > > > > > > > Loïc > > > > > > > > > > > > Le lun. 20 mai 2019 à 15:52, BruceFischl <
> > > fischl@nmr.mgh.harvard.edu> a écrit : > > > > > > Hi Loic > > > > > > > > > > > > if you are on the fsaveragesurface you can save the
> > > -log10(p) values > > > > > > using save_mgh.m, then load themin freeview and
> > > threshold them or > > > > > > whatever > > > > > > > > > > > > cheers > > > > > > Bruce > > > > > > On Mon, 20 May 2019, Loïc Daumailwrote:
> > > > > > > > > > > > > > > > > > > > External Email - UseCaution
> > > > > > > > > > > > > > Also, one more thing: > > > > > > > > > > > > > > My data is on fsaverage5resolution.
> > > > > > > > > > > > > > Thanks in advance, > > > > > > > > > > > > > > Sincerely, > > > > > > > > > > > > > > Loïc > > > > > > > > > > > > > > Le lun. 20 mai 2019 à 09:49,Loïc Daumail <
> > > loic.daumail@gmail.com> a écrit : > > > > > > > Dear Freesurfer community, > > > > > > > > > > > > > > I obtained score matrices ofsurfaces after
> performing > > > diffusion embedding map > > > > > on fMRI > > > > > > data. > > > > > > > > > > > > > > I am now using the SurfStattoolbox(Matlab) in
order > > > to obtain p-value maps to > > > > > compare > > > > > > between > > > > > > > two groups. > > > > > > > > > > > > > > After obtaining the p-valuemap, I would like to
> label > > > the surface in order to > > > > > > identify the > > > > > > > regions of significantdifference between both
> groups. > > > > > > > > > > > > > > Would it be possible to useFreview in order to do
> it? > > > > > > > If so, which format should Iuse for my SurfStatP
> > > output p-value map? > > > > > > > How would you do it, (tools toconvert into a
> specific > > > format, surfaces and > > > > > atlas to > > > > > > load on > > > > > > > Freeview, which format forthose ones)?
> > > > > > > I would be very grateful if youcould detail a
bit, > as > > > I am new to these > > > > > tools! > > > > > > > > > > > > > > Thanks in advance, > > > > > > > > > > > > > > Loïc Daumail > > > > > > > > > > > > > > > > > > > >
> > > > > > Freesurfer mailing list > > > > > > Freesurfer@nmr.mgh.harvard.edu > > > > > > > > >https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> > > > > > > > > > > > > > > > >
> > > > > Freesurfer mailing list > > > > > Freesurfer@nmr.mgh.harvard.edu > > > > >https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> > > > > > > > > > > > > > >_______________________________________________ > > > > Freesurfer mailing list > > > > Freesurfer@nmr.mgh.harvard.edu > > > >https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> > > > > > -- > > > Dr. Tim Schäfer > > > Postdoc Computational Neuroimaging > > > Department of Child and Adolescent Psychiatry,Psychosomatics and
> > > Psychotherapy > > > University Hospital Frankfurt, Goethe UniversityFrankfurt am Main,
> Germany > > > > > > _______________________________________________ > > > Freesurfer mailing list > > > Freesurfer@nmr.mgh.harvard.edu > > >https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> > _______________________________________________ > > Freesurfer mailing list > > Freesurfer@nmr.mgh.harvard.edu > >https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> > _______________________________________________ > Freesurfer mailing list > Freesurfer@nmr.mgh.harvard.edu >https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> > >_______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
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-- Dr. Tim Schäfer Postdoc Computational Neuroimaging Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy University Hospital Frankfurt, Goethe University Frankfurt am Main, Germany