[Freesurfer] bbregister with PET data

Hi Doug and Freesurfer team,

I am trying to coregister some PET maps with their relative high resolution MEMPRAGE files. I was thinking that bbregister might be my best option but the results are still not satisfactory, likely due to the intrinsic features of my radioligand (the resulting maps are quite 'noisy' in terms of anatomical details). Do you have any suggestions on how to improve the results of bbregister (e.g., flags to use, or preprocessing steps prior to running bbregister)?

- the PET map for one subject is here: /autofs/space/katahdin_005/users/marco/PBR28/data/PBR_CLBP001/PET/PBR_CLBP001_average8-28_BET_hdrOK.nii - my SUBJECTS_DIR is here /autofs/space/katahdin_005/users/marco/PBR28/data/ - The command I ran is: bbregister --init-fsl --mov PBR_CLBP001_average8-28_BET_hdrOK.nii --t2 --s PBR_CLBP001 --reg PET2brain.BB.reg --o PET2brain.BB.nii

Thanks!

Marco ______________________________

Marco L. Loggia, PhD Postdoctoral Fellow Massachusetts General Hospital Brigham and Women's Hospital Harvard Medical School

149 Thirteenth Street, Room 2301 Charlestown, MA 02129 Phone: (617) 643-7267 Fax: (617) 726-7422 marco@nmr.mgh.harvard.edu