Hi,
We extracted volume measures from 7 ROIs in 2 groups and compared a) Mean of each ROI volume between group, and compared independently such as i) whether mean of ROI 1 in group 1 is equal to mean of ROI1 in group 2 ii)whether mean of ROI 2 in group 1 is equal to mean of ROI2 in group 2 and so on
b) Plotted the mean ROI volume for 2 independent measures and compared whether the slope between and within group is significantly different. such as i) Slope of ROI1 is positively associated with MoCA , age (grp1) ? ii) Slope of ROI1 is negatively associated with MoCA, age (grp2) ? iii) Slope of ROI1 vs MoCA (grp1) is significantly different than slope of ROI1 vs MoCA (grp2) ? iv) Slope of ROI1 vs MoCA (grp2) is significantly different than slope of ROI2 vs MoCA (grp2) ?
Q1) Do we have to perform multiple comparisons for (a) and (b)? Q2) If yes, do we correct across 7 measurements for (a) and 2 measurements for (b) or 7 measurements for both (a) and (b)?
There is evidence to both performing and nonperforming multiple comparisons In the literature.
Any response (hopefully pointing to a literature) will be greatly appreciated.
Thanks
Regards
--VM