Dear FS experts I'm completely new to the world of freesurfer and apologize my silly queries. I'm trying to compare GM volume, cortical thickness, and mean curvature of 34 automatically parcellated cortical structures (data from 'aparcstats2table' command) between control and patient groups (N=32 for each) using SPSS. Here are my questions.1) It seems reasonable that statistical model of between-group comparison of each cortical GM volume should include age, sex, and intracranial (or cortical total GM volume) as covariates.But, should I also include intracranial volume (or cortical GMV) as a covariate in cases of cortical thickness and mean curvature ?? (Please note what I'm trying to do is NOT whole brain image analysis BUT MANCOVA using SPSS)When searching for the published articles containing cortical thickness analysis identical to what I'm doing, I found some use such a covariate, but some did not.Please let me know the better method. 2) My second questions is not directly related to FreeSurfer.From the above-mentioned analysis (MANCOVA: 2 groups, 34 dependent variables, 2 or 3 covariates), should I correct for multiple comparison problem using Bonferroni corrected P < 0.05/34=0.0014) or FDR-corrected P < 0.05 ?? Once again, apologies for my basic questions.Any comment would be greatly appreciated. Thank you in advance for your kind help. M. KimSouth Korea