[Freesurfer] Interpretation of pcc.mgh for negative contrasts

External Email - Use Caution

Hi List,

a dimple question about using partial correlation (pcc.mgh) as effect size measure. I am running multivariate regression and setting positive and negative contrasts one variable at a time, e.g. a design matrix with columns like

Intercept Age Gender Fact1 Fact2 ....

and a bunch of contrasts like

0 0 0 1 0

0 0 0 -1 0

Now let's say the second contrast gives me a significant results after MC correction in a certain cluster, what sign should i expect in PCC in that cluster (on average)?

Thank you very much in advance,

Nicola