Dear Douglas Greve and FS team,
I send this e-mail again since I was afraid that you would not receive my previous e-mail. I am sorry if you got the previous e-mail and are figuring this problem out.
I am looking forward to receive your reply regarding to the solution.
Thank you.
Best, Seung-Gul
--- *Seung Gul Kang, M.D., Ph.D. *
*Psychiatrist, Associate Professor*; Department of Psychiatry, Gil Medical Center, Gachon University, School of Medicine, 21, Namdong-daero 774 beon-gil, Namdong-gu, Incheon, 21565, South Korea *Research scholar*; Sleep Disorders Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 1 Bowdoin Square, 9th floor, Boston, MA 02114, USA *Collaboration researcher*; Division of Sleep & Circadian Disorders, Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston MA 02115
---------- Forwarded message ---------- From: Seung Gul Kang sg.kang422@gmail.com Date: 2016-09-10 17:49 GMT-04:00 Subject: Re: [Freesurfer] ERROR: matrix is ill-conditioned or badly scaled, condno = 22801.1 To: Freesurfer support list freesurfer@nmr.mgh.harvard.edu
Dear Douglas Greve,
Thank you so much for your answer. But, unfortunately it did not work.
The problem develops when I put bhth (global thickness) as a covariate. (I want to control age, sex, BDINS, and bhth for the comparison between two groups.) If I don't put bhth as a covariate, there is no problem. And, inerestingly, if I put only bhth as a covariate (without putting other covariates), the error does not develop.
Does the normalization mean the log (bhth)? I changed the bhth into log (bhth) and ran qdec again. However, the error appeared again as below. (Actually, the bhth already shows normal distribution in spss.) I am afraid that normalization would not be solution. Please see the file 1 (my FSGD file) and 2 (FSGD file made in qdec folder).
Normalized matrix condition is 16920.4 Design matrix ------------------ 1.000 0.000 0.000 0.000 27.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 0.415 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 28.000 0.000 0.000 0.000 4.000 0.000 0.000 0.000 0.387 0.000; 1.000 0.000 0.000 0.000 25.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 0.400 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 26.000 0.000 0.000 0.000 7.000 0.000 0.000 0.000 0.399 0.000; 1.000 0.000 0.000 0.000 35.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 0.390 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 30.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.376 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 24.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.385 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 24.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 0.379 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 28.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.372 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 33.000 0.000 0.000 0.000 2.000 0.000 0.000 0.000 0.379 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 45.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.362 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 38.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.362 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 24.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.394 0.000; 1.000 0.000 0.000 0.000 28.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.364 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 30.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.390 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 39.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 0.348 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 48.000 0.000 0.000 0.000 4.000 0.000 0.000 0.000 0.382 0.000; 1.000 0.000 0.000 0.000 32.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 0.374 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 32.000 0.000 0.000 0.000 4.000 0.000 0.000 0.000 0.399 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 31.000 0.000 0.000 0.000 2.000 0.000 0.000 0.000 0.376 0.000; 1.000 0.000 0.000 0.000 33.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 0.378 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 33.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 0.405 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 44.000 0.000 0.000 0.000 4.000 0.000 0.000 0.000 0.359 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 41.000 0.000 0.000 0.000 2.000 0.000 0.000 0.000 0.384 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 41.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 0.381 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 43.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 0.384 0.000; 0.000 1.000 0.000 0.000 0.000 21.000 0.000 0.000 0.000 10.000 0.000 0.000 0.000 0.382 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 46.000 0.000 0.000 0.000 13.000 0.000 0.000 0.000 0.382; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 41.000 0.000 0.000 0.000 8.000 0.000 0.000 0.000 0.379; 0.000 1.000 0.000 0.000 0.000 29.000 0.000 0.000 0.000 13.000 0.000 0.000 0.000 0.382 0.000 0.000; 0.000 1.000 0.000 0.000 0.000 39.000 0.000 0.000 0.000 12.000 0.000 0.000 0.000 0.376 0.000 0.000; 0.000 1.000 0.000 0.000 0.000 27.000 0.000 0.000 0.000 6.000 0.000 0.000 0.000 0.374 0.000 0.000; 0.000 1.000 0.000 0.000 0.000 57.000 0.000 0.000 0.000 11.000 0.000 0.000 0.000 0.368 0.000 0.000; 0.000 1.000 0.000 0.000 0.000 24.000 0.000 0.000 0.000 7.000 0.000 0.000 0.000 0.374 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 31.000 0.000 0.000 0.000 11.000 0.000 0.000 0.000 0.366; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 23.000 0.000 0.000 0.000 11.000 0.000 0.000 0.000 0.402; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 34.000 0.000 0.000 0.000 11.000 0.000 0.000 0.000 0.373; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 32.000 0.000 0.000 0.000 10.000 0.000 0.000 0.000 0.411; 0.000 1.000 0.000 0.000 0.000 37.000 0.000 0.000 0.000 2.000 0.000 0.000 0.000 0.409 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 46.000 0.000 0.000 0.000 5.000 0.000 0.000 0.000 0.380; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 48.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 0.375; 0.000 1.000 0.000 0.000 0.000 42.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 0.392 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 54.000 0.000 0.000 0.000 8.000 0.000 0.000 0.000 0.388; 0.000 1.000 0.000 0.000 0.000 30.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.394 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 36.000 0.000 0.000 0.000 12.000 0.000 0.000 0.000 0.379; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 34.000 0.000 0.000 0.000 9.000 0.000 0.000 0.000 0.362; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 38.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.407; -------------------------------- ERROR: matrix is ill-conditioned or badly scaled, condno = 16920.4 -------------------------------- Possible problem with experimental design: Check for duplicate entries and/or lack of range of continuous variables within a class. If you seek help with this problem, make sure to send: 1. Your command line: mri_glmfit --y /mnt/hgfs/share/kang_fs/qdec/Untitled/y.mgh --fsgd /mnt/hgfs/share/kang_fs/qdec/Untitled/qdec.fsgd dods --glmdir /mnt/hgfs/share/kang_fs/qdec/Untitled --surf fsaverage lh --label /mnt/hgfs/share/kang_fs/fsaverage/label/lh.aparc.label --C /mnt/hgfs/share/kang_fs/qdec/Untitled/contrasts/lh-Avg-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/Untitled/contrasts/lh-Diff-H-I-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/Untitled/contrasts/lh-Diff-M-F-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/Untitled/contrasts/lh-X- diagnosis-sex-Intercept-thickness.mat 2. The FSGD file (if using one) 3. And the design matrix above Error in Analyze: command failed: mri_glmfit --y /mnt/hgfs/share/kang_fs/qdec/Untitled/y.mgh --fsgd /mnt/hgfs/share/kang_fs/qdec/Untitled/qdec.fsgd dods --glmdir /mnt/hgfs/share/kang_fs/qdec/Untitled --surf fsaverage lh --label /mnt/hgfs/share/kang_fs/fsaverage/label/lh.aparc.label --C /mnt/hgfs/share/kang_fs/qdec/Untitled/contrasts/lh-Avg-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/Untitled/contrasts/lh-Diff-H-I-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/Untitled/contrasts/lh-Diff-M-F-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/Untitled/contrasts/lh-X- diagnosis-sex-Intercept-thickness.mat
After error message, I tried to put two lines into my FSGD file (file 3) I put two lines into the below of the variables of the last subject. But, I saw the error message again as below (blue letters). Please check the file 3 (my FSGD file) and file 4 (made by qdec fsgd file).
============================================================ Data table loading completed successfully. SUBJECTS_DIR is '/mnt/hgfs/share/kang_fs' ERROR: QdecGlmDesign::GenerateContrasts: factor 1 must have 2 levels ninputs = 47 Checking inputs nframestot = 47 Allocing output Done allocing nframes = 47 Writing to /mnt/hgfs/share/kang_fs/qdec/Untitled/y.mgh gdfReadHeader: reading /mnt/hgfs/share/kang_fs/qdec/Untitled/qdec.fsgd WARNING: gdfReadV1: class diagnosis1-sexM is defined but not used. INFO: DeMeanFlag keyword not found, DeMeaning will NOT be done. Continuous Variable Means (all subjects) 0 age 34.7021 8.43225 1 BDINS 4.46809 4.30661 2 bhth 2.41468 0.0807373 Class Means of each Continuous Variable 1 diagnosisH-sexM 31.2727 1.5455 2.4318 2 diagnosisI-sexM 34.0000 7.1111 2.4200 3 diagnosis1-sexM -nan -nan -nan 4 diagnosisH-sexF 34.5333 2.0000 2.3940 5 diagnosisI-sexF 38.5833 8.2500 2.4208 6 diagnosis1-sexF -nan -nan -nan INFO: gd2mtx_method is dods Reading source surface /mnt/hgfs/share/kang_fs/fsaverage/surf/lh.white ERROR: no contrasts specified. Error in Analyze: command failed: mri_glmfit --y /mnt/hgfs/share/kang_fs/qdec/Untitled/y.mgh --fsgd /mnt/hgfs/share/kang_fs/qdec/Untitled/qdec.fsgd dods --glmdir /mnt/hgfs/share/kang_fs/qdec/Untitled --surf fsaverage lh --label /mnt/hgfs/share/kang_fs/fsaverage/label/lh.aparc.label
I hope that you could solve this problem. I will really appreciate if you help.
Best, Seung-Gul ᐧ
--- *Seung Gul Kang, M.D., Ph.D. *
*Psychiatrist, Associate Professor*; Department of Psychiatry, Gil Medical Center, Gachon University, School of Medicine, 21, Namdong-daero 774 beon-gil, Namdong-gu, Incheon, 21565, South Korea *Research scholar*; Sleep Disorders Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 1 Bowdoin Square, 9th floor, Boston, MA 02114, USA *Collaboration researcher*; Division of Sleep & Circadian Disorders, Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston MA 02115
2016-09-10 11:42 GMT-04:00 Douglas Greve greve@nmr.mgh.harvard.edu:
You can try normalizing your covariates. You can do so before putting them into the fsgd file or you can add the following two lines to your fsgd file:
DeMeanFlag 1
ReScaleFlag 1
On 9/9/16 11:25 PM, Seung Gul Kang wrote:
Hi,
I am new learner in freesurfer and analyzing the difference of the thickness between two groups using qdec.
There is a error as below. I don't know what is the reason.
ERROR: matrix is ill-conditioned or badly scaled, condno = 22801.1
Possible problem with experimental design: Check for duplicate entries and/or lack of range of continuous variables within a class. If you seek help with this problem, make sure to send:
- Your command line:
mri_glmfit --y /mnt/hgfs/share/kang_fs/qdec/2/y.mgh --fsgd/mnt/hgfs/share/kang_fs/qdec/2/qdec.fsgd dods --glmdir /mnt/hgfs/share/kang_fs/qdec/2 --surf fsaverage lh --label /mnt/hgfs/share/kang_fs/fsaverage/label/lh.aparc.label --C /mnt/hgfs/share/kang_fs/qdec/2/contrasts/lh-Avg-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/2/contrasts/lh-Diff-H-I-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/2/contrasts/lh-Diff-M-F-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/2/contrasts/lh-X-diagnosis-sex- Intercept-thickness.mat 2. The FSGD file (if using one) 3. And the design matrix above Error in Analyze: command failed: mri_glmfit --y /mnt/hgfs/share/kang_fs/qdec/2/y.mgh --fsgd /mnt/hgfs/share/kang_fs/qdec/2/qdec.fsgd dods --glmdir /mnt/hgfs/share/kang_fs/qdec/2 --surf fsaverage lh --label /mnt/hgfs/share/kang_fs/fsaverage/label/lh.aparc.label --C /mnt/hgfs/share/kang_fs/qdec/2/contrasts/lh-Avg-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/2/contrasts/lh-Diff-H-I-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/2/contrasts/lh-Diff-M-F-Intercept-thickness.mat --C /mnt/hgfs/share/kang_fs/qdec/2/contrasts/lh-X-diagnosis-sex- Intercept-thickness.mat
matrix
Design matrix ------------------ 1.000 0.000 0.000 0.000 27.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 2.600 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 28.000 0.000 0.000 0.000 4.000 0.000 0.000 0.000 2.440 0.000; 1.000 0.000 0.000 0.000 25.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 2.510 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 26.000 0.000 0.000 0.000 7.000 0.000 0.000 0.000 2.500 0.000; 1.000 0.000 0.000 0.000 35.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 2.450 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 30.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.380 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 24.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.430 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 24.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 2.390 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 28.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.350 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 33.000 0.000 0.000 0.000 2.000 0.000 0.000 0.000 2.400 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 45.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.300 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 38.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.300 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 24.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.480 0.000; 1.000 0.000 0.000 0.000 28.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.310 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 30.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.460 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 39.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 2.230 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 48.000 0.000 0.000 0.000 4.000 0.000 0.000 0.000 2.410 0.000; 1.000 0.000 0.000 0.000 32.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 2.370 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 32.000 0.000 0.000 0.000 4.000 0.000 0.000 0.000 2.510 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 31.000 0.000 0.000 0.000 2.000 0.000 0.000 0.000 2.380 0.000; 1.000 0.000 0.000 0.000 33.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 2.390 0.000 0.000 0.000; 1.000 0.000 0.000 0.000 33.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 2.540 0.000 0.000 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 44.000 0.000 0.000 0.000 4.000 0.000 0.000 0.000 2.290 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 41.000 0.000 0.000 0.000 2.000 0.000 0.000 0.000 2.420 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 41.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 2.400 0.000; 0.000 0.000 1.000 0.000 0.000 0.000 43.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 2.420 0.000; 0.000 1.000 0.000 0.000 0.000 21.000 0.000 0.000 0.000 10.000 0.000 0.000 0.000 2.410 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 46.000 0.000 0.000 0.000 13.000 0.000 0.000 0.000 2.410; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 41.000 0.000 0.000 0.000 8.000 0.000 0.000 0.000 2.400; 0.000 1.000 0.000 0.000 0.000 29.000 0.000 0.000 0.000 13.000 0.000 0.000 0.000 2.400 0.000 0.000; 0.000 1.000 0.000 0.000 0.000 39.000 0.000 0.000 0.000 12.000 0.000 0.000 0.000 2.380 0.000 0.000; 0.000 1.000 0.000 0.000 0.000 27.000 0.000 0.000 0.000 6.000 0.000 0.000 0.000 2.370 0.000 0.000; 0.000 1.000 0.000 0.000 0.000 57.000 0.000 0.000 0.000 11.000 0.000 0.000 0.000 2.330 0.000 0.000; 0.000 1.000 0.000 0.000 0.000 24.000 0.000 0.000 0.000 7.000 0.000 0.000 0.000 2.370 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 31.000 0.000 0.000 0.000 11.000 0.000 0.000 0.000 2.330; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 23.000 0.000 0.000 0.000 11.000 0.000 0.000 0.000 2.520; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 34.000 0.000 0.000 0.000 11.000 0.000 0.000 0.000 2.360; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 32.000 0.000 0.000 0.000 10.000 0.000 0.000 0.000 2.570; 0.000 1.000 0.000 0.000 0.000 37.000 0.000 0.000 0.000 2.000 0.000 0.000 0.000 2.570 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 46.000 0.000 0.000 0.000 5.000 0.000 0.000 0.000 2.400; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 48.000 0.000 0.000 0.000 1.000 0.000 0.000 0.000 2.370; 0.000 1.000 0.000 0.000 0.000 42.000 0.000 0.000 0.000 3.000 0.000 0.000 0.000 2.470 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 54.000 0.000 0.000 0.000 8.000 0.000 0.000 0.000 2.450; 0.000 1.000 0.000 0.000 0.000 30.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.480 0.000 0.000; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 36.000 0.000 0.000 0.000 12.000 0.000 0.000 0.000 2.390; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 34.000 0.000 0.000 0.000 9.000 0.000 0.000 0.000 2.300; 0.000 0.000 0.000 1.000 0.000 0.000 0.000 38.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 2.550;
I attached fsgd file.
Thank you.
Best, Seung-Gul
*Seung Gul Kang, M.D., Ph.D. *
*Psychiatrist, Associate Professor*; Department of Psychiatry, Gil Medical Center, Gachon University, School of Medicine, 21, Namdong-daero 774 beon-gil, Namdong-gu, Incheon, 21565, South Korea *Research scholar*; Sleep Disorders Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 1 Bowdoin Square, 9th floor, Boston, MA 02114, USA *Collaboration researcher*; Division of Sleep & Circadian Disorders, Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston MA 02115
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