Dear Freesurfer community,
I am working on an ROI analysis using qdec. I have created all aseg and aparc stats files and would like to determine if there are any differences in volume, surface area, and thickness for certain structures between two groups. I was wondering with the analysis, would it be okay to use the resulting aseg/aparc output stats from either the Desikan/Destrieux atlases and run these values through SPSS or is it better to draw ROI labels on the fsaverage brain, apply the label to each subject, and run the analyses this way. I am asking because the following tutorial states:
*"Note*: If you want to use a pre-existing label and register it to fsaverage, be aware that this might involve two instances of resampling and the results might not be as accurate as they would be if you drew the label on fsaverage. Please contact the FreeSurfer team to get more details on this process if you have any concerns."
http://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/AnatomicalROI#Tableofthe...
If drawing labels on the fsaverage brain and applying them to each subject is the way to go- would I need to correct for multiple comparisons?
Many thanks, Larissa