Hello-
I am trying to analyze the cortical thickness between two groups of subjects Cl1 and CL2. When i run the GLM i receive the error:
matrix is ill-conditioned or badly scaled, condno = 1e+08
I am under the impression the error could be due to the non-uniformity in the range/scale of the regressors.
here is my information:
contrast is 1 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
1) mri_glmfit --y lh.PvNPeverything.10.mgh --fsgd PvNPeverything.fsgd dods --C PvNP_everything.mtx --surf UNM_ALLGOOD lh --cortex --glmdir lh.PvNPeverything.glmdir
2) (sample of my fsgd) - there are no columns with all 0's in them GroupDescriptorFile 1 Title Methedone Comparison Class Cl1 Class Cl2 Variables WAISIQ trait_anxiety alcohol_year heroin_year cocaine_year cannabis_year meth_year amphetamines_year meth_amphet_year hallucinogens_year inhalants_year methodne_year opiates_year pills_year opitates_pills_year other_year total_years Input M87160505 Cl1 86 33 10 3 9 11 0 1 1 1 8 0 0 6 6 0 49 Input M87161888 Cl1 109 59 0 0 7 22 0 0 0 0 0 0 0 0 0 0 32 Input M87107477 Cl1 89 34 12 0 9 13 0 9 9 6 10 0 1 9 10 0 57 Input M87199897 Cl1 117 44 0 23 0 10 0 0 0 0 0 9 15 0 15 3 60 Input M87146570 Cl1 94 42 26 0 3 8 0 0 0 0 0 0 0 0 0 6 37 Input M87189755 Cl1 111 59 11 0.5 2 15 0 3 3 1.5 0 0 0 0 0 0 36 Input M87169696 Cl1 86 22 2 0 11 14 0 0 0 0 0 0 0 0 0 0 25 Input M87187366 Cl1 106 51 28 0 27 0 0 20 20 0 0 0 0 0 0 0 75 Input M87178857 Cl2 117 48 0 4 4 8 0 5 5 7 0 4 0 0.08 0.08 0 42.08 Input M87165923 Cl2 103 40 5 2 0 15 0 0 0 0 0 0 0 1 1 0 23 Input M87110556 Cl2 134 60 4 0 1 15 0 0 0 0 0 0 0 0 0 0 20 Input M87183811 Cl2 97 43 15 0 8 3 0 0 0 0 0 0 0 0 0 0 26
3) design matrix
1 0 86 0 33 0 10 0 3 0 9 0 11 0 0 0 1 0 1 0 1 0 8 0 0 0 0 0 6 0 6 0 0 0 49 0 1 0 109 0 59 0 0 0 0 0 7 0 22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 32 0 1 0 89 0 34 0 12 0 0 0 9 0 13 0 0 0 9 0 9 0 6 0 10 0 0 0 1 0 9 0 10 0 0 0 57 0 1 0 89 0 40 0 15 0 5 0 2 0 30 0 10 0 0 0 10 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 59 0 1 0 77 0 44 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 1 0 91 0 22 0 6 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 1 0 103 0 29 0 20 0 3 0 11 0 27 0 0 0 11 0 11 0 5 0 0 0 0 0 0 0 1 0 1 0 0 0 78 0 1 0 117 0 44 0 0 0 23 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 9 0 15 0 0 0 15 0 3 0 60 0 1 0 94 0 42 0 26 0 0 0 3 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 37 0 1 0 91 0 38 0 20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 0 1 0 86 0 45 0 3 0 1 0 2 0 7 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 1 0 1 0 14 0 1 0 114 0 50 0 5 0 1 0 3 0 10 0 0 0 0.08 0 0.08 0 0 0 0 0 0.33 0 1 0 0 0 1 0 0 0 20.42 0 1 0 109 0 27 0 5 0 5 0 4 0 14 0 0 0 0 0 0 0 5 0 0 0 0 0 1 0 4 0 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