There's some reference of test-retest reliability here: http://surfer.nmr.mgh.harvard.edu/fswiki/FreeSurferMethodsCitation, although I doubt it's complete. There's also a section on the wiki of paper evaluating freesurfer: http://surfer.nmr.mgh.harvard.edu/fswiki/#Articles.evaluations

What I know off hand is that for cytoarchitectonics and some function (like MT+ and V1), freesurfer registration accuracy ranges from 2-3mm (V1) to 6-12mm (BA44, BA45, MT+). BA2, BA6, etc in between. Here's the references:

Fischl et al. 2008 Cortical folding patterns and predicting cytoarchitecture Hinds et al. 2008 Accurate prediction of V1 location from cortical folds in a surface coordinate system Yeo et al. 2008 Spherical Demons: Fast Diffeomorphic Landmark-Free Surface Registration Yeo et al. 2010 Learning Task-Optimal Registration Cost Functions for Localizing Cytoarchitecture and Function in the Cerebral Cortex

--Thomas

On Sat, Dec 17, 2011 at 5:49 AM, MCLAREN, Donald mclaren.donald@gmail.com wrote:

I've looked through a number of freesurfer papers, but haven't been able to find the answer to what I am looking for and was hoping someone had the references easily available.

(1) What is the reliability of regional volumes generated from freesurfer over time?

(2) What is the accuracy of labels for these volumes from subject to subject (e.g. how close are the freesurfer labels to cytoarchitecture or manually drawing the labels)?

Best Regards, Donald McLaren

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