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Our group is trying to decide on whether we should move to FS8/clinical recon all indefinitely, however we note some inconsistencies. In some instances, SynthSeg seems to completely ignore the underlying structure and “imputes” tissue. Cortical thickness estimates are overall most different from FS7, as may be expected, however, in some cases volumes (e.g., hippocampus) may also be overestimated.
We have 1mm isotropic T1s, which I see that recon-all may be "generally more accurate than recon-all-clinical.” We’re looking to take advantage of SynthSeg’s ability to overcome poor data quality/dropout/complex folding etc., but do not want to necessarily “in-paint normal looking tissue.” Can you provide any additional information or guidance on the best path forward?
Thank you very much for your time and any guidance!
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