Dear FreeSurfer team,
I'm currently doing a structural FS analysis with 50 Multiple Sclerosis (MS) patients and 25 Healthy Controls (HC). FLAIR-lesions were drawn onto the aseg.mgz as White Matter Hypointensities (=77). I've finished the analysis, but have some questions regarding my results.
Results:
HC (n=25)
MS (n=50)
p-value
Mean TIV (SD) [ml]
1594.9 (154.7)
1559.5 (140.1)
0.05
Mean WMV (SD) [ml]
503.6 (57.3)
485.2 (59.5)
0.05
Mean GMV (SD) [ml]
657.2 (69.9)
635.1 (47.9)
0.05
Mean WMHV (SD) [ml]
1.12 (0.4)
5.97 (5.7)
0.0000677
1) Does these results look correct? WMV < GMV?
2) What is the difference between WMV+GMV and TIV? CSF? Ventricles?
3) I find no atrophy in the MS patients; are there reported any problems with FS and MS patients?
4) What is White Matter Hypointensities comprised of in HC?
Best, Silas