Hi Jeff, I personally like the idea of using average thickness as a covariate to control for a reduction in "whole brain" thickness, and have used that approach in a paper. If the Abstract that you mentioned indicated that this is flawed, I'd be curious to know what the reason was...
cheers, -MH
On Thu, 2012-03-22 at 21:00 -0400, Bruce Fischl wrote:
Hi Jeff
yes, I think this is still our recommendation for thickness, although perhaps David Salat can verify. As far as surface area, you might get Anderson Winkler to send you a preprint of his newly accepted paper on surface area comparisons and how to do them properly. I would have said normalize by the 2/3 root of ICV (maybe David can comment on this as well)
cheers Bruce
On Thu, 22 Mar 2012, Jeff Sadino wrote:
Hello, For cortical thickness normalizations, Bruce said not to normalize based on a HBM abstract (http://www.mail-archive.com/freesurfer@nmr.mgh.harvard.edu/msg06646.html). Is this still the consensus?
For cortical volume, it is pretty standard to normalize to eTIV.
For cortical surface area (jacobian), I couldn't find any information on the wiki. Does anyone have any recommendations?
Thank you, Jeff
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