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To whom it may concern, Hello! We are currently trying to do a ST-LME (Spatiotemporal-LME) analysis based on bipolar disorder brain MRI images. We are having 2 problems: 1)In the lme_mass_fit_EMinit step, we get a warning that says matrix is singular, close to singular or badly scaled. 2)In the lme_mass_RgGrow step, it says "computing seeds" indefinitely and it never ends. We looked for people having similar problems, however we could not find a solution. Currently, we suspect that this may be due to the zeros in the columns of fs_read_Y('lh.thickness_sm10.mgh'). Do you happen to know the reasons of these problems? Thank you for your time. Sincerely,Yıldırım Adalıoğlu