Hello all
I have seen in the articles:
-Freeborough, P.A., Fox, N.C., 1997. The boundary shift integral: an accurate and robust measure of cerebral volume changes from registered repeat MRI. IEEE Trans. Med. Imaging 16, 623- 629.
- Kewei Chen et. all. An automated algorithm for the computation of brain volume change from sequential MRIs using an iterative principal component analysis and its evaluation for the assessment of whole-brain atrophy rates in patients probable with Alzheimer's disease. NeuroImage 22 (2004)
That measures are obtained to estimate the whole-brain atrophy rates in patients with probable Alzheimer's disease and controls.
Can I get the same thing by using the calculated intracranial volume (whole-brain) obtained from freesurfer after Skull Streaping and computing the differences for these volumes for the sequential images?
Could these two analyses be equivalent in the sense that both they would give me whole-brain atrophy rates? So, if I have intracranial volume calculated why I would need BSI?.
I have the same doubt for hippocampus volume comparisons for sequential images. Can I use a volume calculated from freesurfer subcortical segmentation or again I will need BSI or some other measure?
In advance, thank you
Jorge
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