Hi Don

there is a nonlinear offset filter (Fischl and Schwartz, 1999, IEEE PAMI) applied during the segmentation process internally, but no filtered images are ever written to disk. You can try it out with mri_nlfilter. In general I would rather incorporate the information in the filtering into the segmentation than have some black box run beforehand that the segmentation doesn't know about, but of course that's not feasible for every filter under the sun. Whether it will help or not probably depends a lot on the quality of the input data.

Let us know how it goes.

cheers Bruce

On Fri, 14 Oct 2011, MCLAREN, Donald wrote:

Bruce and others,

Are there any spatial filters applied during the segmentation process other than a bias field correction? For example, a spatially adaptive non-linear means filter (e.g VBM8)?

If not, do you think denoising filters will improve the accuracy and/or reduce manual editting?

Thanks.

Best Regards, Donald McLaren

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