Mark,
once I had a similar problem on an autopsied brain, where it was very difficult to obtain an MPRAGE-like contrast. So instead, I acquired T2-weighted and inverted it. This gave me contrast very similar to MPRAGE, though my analysis failed anyway, due to too strong bias field. So you might want to give it a try and invert your image intensity.
Best,
Marin
On Monday 20 October 2008 19:48:05 Bruce Fischl wrote:
Hi Mark,
if wm is darker than gm our tools probably will not work. You might try using the FSL segmentation tools and putting the output of them through our stream for surface-based analysis.
cheers, Bruce