Our reply to that is here http://bjp.rcpsych.org/content/196/5/414.2.long
which reminded me of other papers that have also used a global thickness measure to covary for mean cortical thickness and thereby "address whether any regional thickness differences were in excess of global cortical thickness differences between groups" -- see references [1,4] in our Reply.
cheers, -MH
Hi Michael and others,
maybe it's this one:
http://bjp.rcpsych.org/content/196/5/414.1.long
best, -joost
On Fri, Mar 23, 2012 at 2:15 AM, Michael Harms mharms@conte.wustl.eduwrote:
Hi Jeff, I personally like the idea of using average thickness as a covariate to control for a reduction in "whole brain" thickness, and have used that approach in a paper. If the Abstract that you mentioned indicated that this is flawed, I'd be curious to know what the reason was...
cheers, -MH
On Thu, 2012-03-22 at 21:00 -0400, Bruce Fischl wrote:
Hi Jeff
yes, I think this is still our recommendation for thickness, although perhaps David Salat can verify. As far as surface area, you might get Anderson Winkler to send you a preprint of his newly accepted paper on surface area comparisons and how to do them properly. I would have
said
normalize by the 2/3 root of ICV (maybe David can comment on this as
well)
cheers Bruce
On Thu, 22 Mar 2012, Jeff Sadino wrote:
Hello, For cortical thickness normalizations, Bruce said not to normalize
based on a HBM
abstract (
http://www.mail-archive.com/freesurfer@nmr.mgh.harvard.edu/msg06646.html). Is
this still the consensus?
For cortical volume, it is pretty standard to normalize to eTIV.
For cortical surface area (jacobian), I couldn't find any
information on the wiki.
Does anyone have any recommendations?
Thank you, Jeff
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