Any software package will do the inference on images with different characteristics, the question is whether the inference is valid. If you use different types of images, you will get different results (all software packages). If you try to compare two groups each with image types, you will have a confound with your image type and your groups and the inference will not be valid. Having said that, if you want to analyze some of your subject with T1 and some with T1+T2 and some with T1+FLAIR, then can certainly do so.
On 2/13/2020 8:13 AM, Renew Andrade wrote:
External Email - Use CautionDear FreeSurfer experts:
I am dealing with a crossectional retrospective case control study where I don't have all subjects with the same inaging protocols. I do have T1 for all of them although some have T2 others FLAIR others T2+FLAIR (besides T1 for all of them). My question is regarding VBM can I do inference on images with different characteristics? Or should them all have T1 + T2 or T1 + FLAIR. I guess this is the case that is all subjects should be processed with the same protocols. This is in Multiple Sclerosis by the way just in case it matters.
Sincerely, Andrade.
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