Hi Mehul,
I would use mri_robust_register, but otherwise I think it should work (assuming the lesion hasn't changed in size)
Bruce
On Wed, 11 Aug 2010, Mehul Sampat wrote:
Hi Folks,
I have two MR scans per subject. Lesions (white matter hypo-intensities) have been manually outlined for the first time-point.
I would like to create a lesion mask for the 2nd time-point. But instead of starting from scratch, I would like to use the lesion-mask from the 1st time-point as a starting point for the lesion mask for time-point 2.
for this task, I think I can use the following steps:
Step 1) Register 1st time-point to the 2nd scan (using 2nd timepoint as reference) with flirt Step 2) Use mri_convert to apply the transformation matrix from flirt to the lesion mask and create a lesion mask for time-point 2. Step 3) make corrections to the lesion mask for time-point 2 if required.
Would you suggest to do it in this manner or is an alternative approach recommended ? thanks Mehul ps: I thought of using the longitudinal freesurfer pipeline but i dont know how to compute the transformation matrix from time-point 1 to time-point 2 use the pipeline...