[Freesurfer] total gray and white matter volumes, and total brain volume

Hi all,

I am calculating total gray and white matter volumes using mrs_volume and mris_wm_volume, and I wanted to clarify what these are measuring. I am following the instructions on the morphometry stats wiki page, which say to use mris_volume and subract wm from pial volume to get total gray matter. Will this leave me with all gray matter including cortical and subcortical? Then I use mris_wm_volume to calculate total wm. Again, does this include all white matter in the brain?

Also, what would be the best way to calculate total brain volume? I could add the calculations for gray matter and white matter described above, or I could use BrainSetNotVen from the aseg stats file, or I could add all the structures in the aparc and aseg files. Any recommendation on which is best?

Thanks, Dana

Dana W. Moore, Ph.D. Neuropsychology Fellow Cornell Neuropsychology Service Weill Medical College of Cornell University New York Presbyterian Hospital Department of Neurology & Neuroscience 428 East 72nd Street, Suite 500 New York, NY 10021 Phone: 212-746-2441 Fax: 212-746-5584 Email: dwm2003@med.cornell.edu