Hi Martina
no, probably not. We use the geometry of the gray/white boundary to drive the registration and segmentation, and it is completely invariant to gray matter atrophy and it would take huge amounts of white matter atrophy to cahnge it enough to mess things up.
cheers Bruce On Tue, 11 Nov 2014, Martina Papmeyer wrote:
Dear FreeSurfer experts
I have one question regarding the labeling of cortical structures using the Desikan-Killiany atlas and couldn't find any information in the archives. As far as I read, this atlas has been composed by including 40 subjects of broad age ranges (19-86 years of age), with 10 of them suffering from Alzheimer's disease. Since I am mainly working with data sets of much younger non-demented subjects (early twenties), I was wondering if it was more accurate to make use of a young subset of the Desikan-Killiany atlas to optimize the labeling of cortical parcellations and if that was possible at all?
Thank you very much for your help!
All best wishes Martina