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Hello all,
I am using FreeSurfer to measure specific cortical parcellations and subcortical segmentations in a medium-sized dataset (over 150 scans). About a fifth of the scans include cortical lesions (ischemic stroke, hemorrhagic stroke, focal traumatic injuries, neoplasm) that visibly disrupt recon-all's white matter surface and the pial surface locally at the lesion.
Assuming there is no midline shift, does the recon-all processing stream perform segmentations and parcellations in each hemisphere independently? Or, could a unilateral lesion impact segmentation/parcellation on the contralateral side?
For segmentation/parcellation measurements on the side ipsilateral to a lesion, how robust are recon-all's measurements in non-lesioned regions? For instance, are hippocampal volume measurements impacted by a cortical lesion in the frontal convexity? Or a lesion in a lateral temporal gyrus? Are there any general guides on how close a lesion can be to a ROI before automated measurements are invalid?
Thank you much in advance, Brian -- L. Brian Hickman, MD, MSc
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