I'm not sure whether the Freesurfer list is the appropriate place for this discussion or not, however I'll place the question here and if somebody has an idea we can discuss by pm. Regarding the paper: Focal thinning of the cerebral cortex in multiple sclerosis ( http://www.nmr.mgh.harvard.edu/~fischl/reprints/Brain2003v126p1734Sailercort... )
AFAIK is the only paper using FreeSurfer to study Multiple Sclerosis. I have a PhD student who is conducting a similar study from the above mentioned paper using FreeSurfer and after data analysis we have some questions:
1) The focal thinning pattern we found is similar to the one described in Sailer's paper. Since that paper is from 2003 I suppose the 4.3 version of FreeSurfer produce results more accurate than that. So confirming that data is an important finding?
2) Studying aseg data we found important atrophy of basal ganglia and corpus callosum. Is the FreeSurfer segmentation accurate enough in presence of MS lesions in T1 imges?
3) The atrophy in corpus callosum is not accompanied by cortical thickness reduction close to this area. Speaking in general: can we think that this atrophy that affects white matter only is caused by misclassified focal lesion?
Thanks in advance for any comments.
PPJ ----------------------------------------------------------- Pedro Paulo de M. Oliveira Junior Diretor de Operações Netfilter & SpeedComm Telecom --- Novo Netfilter 3.0 www.netfilter.com.br