Please be (much) more specific. What are the regions that you are finding changes in? Can you provide some numbers? There are big differences between v8 and v7 so it does not totally surprise me.
On 8/7/2025 1:40 AM, Hana McMahon wrote:
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Hi,
I’ve processed the same set of T1‐weighted scans with both FreeSurfer v7.2.0 and the newer v8.0.0. When I compare the regional stats (aseg + subfield tables), the absolute proportional differences are surprisingly large (anywhere from ~1 % up to nearly 200 %, depending on the structure).
I first noticed the issue while running ANCOVAs: with the v8 outputs, estimated total intracranial volume (eTIV) is highly significant in every model, whereas the v7 results (using identical R code and covariates) show a very different pattern.
I am wondering:
- Are these version‐to‐version shifts expected, given the changes in v8?
- Have others reported similar magnitude differences, particularly for eTIV and subcortical/hippocampal measures?
- Are large shifts expected from run-to-run as well?
Any insight would be greatly appreciated, as I am concerned by the magnitude of the differences I am seeing between versions, which are significantly changing my results.
Thanks for your time.
Kindest, Hana
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