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Dear Rui,
there is no hard limit to resolution. Your data should have a decent quality (no motion artifacts, high SNR, high contrast, isotropic resolution) and the suggestions of the submillimeter reconstruction should give good results. I have run FreeSurfer on 250 µm human data with reasonable, but improvable results. Still working on it.
From my experience skull stripping seems to fail using data with higher resolution than 0.7 mm. Therefore, I suggest you to follow the first steps of the guideline: https://surfer.nmr.mgh.harvard.edu/fswiki/HiResRecon to create a low resolution brainmask, upsampling, and applying it on your high resolution data. Apart from that everything should run smoothly.
Expect it to run for a few weeks, especially the topological fixation and autorecon3 will take time.
Best, Falk
Von: freesurfer-bounces@nmr.mgh.harvard.edu [mailto:freesurfer-bounces@nmr.mgh.harvard.edu] Im Auftrag von Nian Rui Gesendet: Donnerstag, 18. Oktober 2018 00:50 An: freesurfer@nmr.mgh.harvard.edu Betreff: [Freesurfer] Ask for your help about freesurfer submillimeter reconstruction! Priorität: Hoch
External Email - Use Caution Dear FreeSurfer Developers,
I am now working on the analysis of MRI images with the voxel resolution less than 0.2mm3. I read your webpage about submillimeter reconstruction, https://urldefense.proofpoint.com/v2/url?u=https-3A__surfer.nmr.mgh.harvard...., which said Freesurfer 6.0 works well for voxel sizes 0.75 mm3, and inputs with 0.5 mm3 voxels or below will have a brainmask failure (we are working on it!). So I am writing to ask for your help about the reconstruction with freesurfer. I would like to know, have you solved the higher resolution problem in the new version v6.0? Could I use it to analyze the cortical thickness of these MRI images now? If not, is there any other way to help processing these MRI images and we could run freesurfer step by step for evaluation? Look forward to your timely help! Thanks a lot in advance! yours sincerely, Rui