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Hi Freesurfer Mailing List,
I work on a large bipolar disorder imaging study that has been running for over 10 years. We previously acquired 2 sMRI time-points (pre 2013, n ~500, n ~250 at each time-point) on a single Philips 3T scanner and these images were processed with Freesurfer version 5.3. We have just now acquired a third imaging time-point that was completed on a different scanner (Siemans, n ~120) using a different acquisition protocal. So I have three questions for the mailing list, that I'm hoping will inform the design of our analysis protocol:
1. Are there specific considerations for processing structural MRIs that have been acquired on different scanners and with different acquisition protocols? 2. Reprocessing all time 1 and time 2 images with a newer version of Freesurfer is a huge undertaking (for both processing time and personnel time required to review and edit). However, is there a reason why a newer version of Freesurfer should be used (e.g. publication considerations, more consistent output) as opposed to processing time 3 with v5.3? 3. I know there are differences in the output across different versions of Freesurfer. However, do different system set ups (e.g. linux, mac, as well as operating systems) have an impact on the output, even if the same version of Freesurfer is used?
Kind regards,
Bronwyn Overs
Research Assistant
Neuroscience Research Australia Margarete Ainsworth Building Barker Street Randwick Sydney NSW 2031 Australia M 0411 308 769 T +61 2 9399 1725
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