Hi Yunus
I think typically you would normalize by eTIV^(2/3), which would result in a dimensionless scaling
Cheers Bruce
From: freesurfer-bounces@nmr.mgh.harvard.edu freesurfer-bounces@nmr.mgh.harvard.edu On Behalf Of yunus soleymani Sent: Friday, May 3, 2024 3:31 AM To: freesurfer@nmr.mgh.harvard.edu Subject: [Freesurfer] surface and cortical thickness normalization
External Email - Use Caution Hello,
I hope you are doing well. Yesterday, I had some questions regarding normalization in Freesurfer. Thanks to Dr. Douglas N. Greve, I received answers for all of them. However, I still have one more question.
When I normalize brain surfaces to eTIV, they appear to be in two different units (mm2 and mm3). Will this be a problem? Additionally, I would like to know your thoughts on normalizing cortical thicknesses. Do you think they should be normalized to eTIV, or would it be better to normalize them to the mean cortical thickness of each subject?
I would greatly appreciate your response.
Thank you, Yunus
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Yunus Soleymani
Ph.D. Candidate of Neuroimaging
Tehran University of Medical Sciences
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