<p>Dear FS experts,<br />I use qdec to do two group study. in QDEC, it set Normal = 1 and Disease = 2, use AGE as covariate and apply DODS model, after analyze group cortical thickness, it showed significant negative T value (blue color) in some brain areas. I have two questions in qdec<br />1. the contrast  set as 1 -1 0 0 but I don't know if it represents as Normal - Disease (normal group is thinner than Disease) or Disease - Normal (disease group is thinner than normal) ?<br />2. is this results come from correction of multiple comparison ? or I still need to re-set FDR level (default is 0.05) and re-run it ?<br />thanks in advance<br />JLH</p>