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Dear All,

I have a problem with the Freesurfer hippocampal longitudinal segmentation results , when i have done segmentation using following algorithm ( https://github.com/CobraLab/antsRegistration-MAGeT) with no anterior/posterior partitioning ( Head/body/tail ) , on my subject pool the volumes that i have obtained for each subfield is very different from the volumes of corresponding subfields that i am getting when i have done subfield segmentation using freesurfer. I think algorithm does influence the segmentation procedure, if this is the case then i am getting different results for histology based segmentation using https://github.com/CobraLab/antsRegistration-MAGeT and freesurfer.

When i compare the subfield volumes between healthy and disease patients that i have obtained using first segmentation procedure using ANTS-MAGeT , i notice statistical significance in subfields like CA1,CA2-CA3 but when i do the same using freesurfer based algorithm i notice no statistical significance in these subfields.

Do you think the algorithm has any influence on segmentation to such a level that we get completely different results on two occasions.

Thanks Vasudev