I think these usually show up in putamen/pallidum, in which case they are probably mineralization, a virchow-robin space, or maybe a subcortical stroke.

On 9/18/2020 11:28 AM, L wrote:

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Dear experts,

I am wondering what the non-white matter hypointensity refers to. Does it refer to hypointensity in subcortical regions or all brain regions except white matter? When we do data analysis using volume results from ROI tables, we found a greater volume of non-wm hypointensity in depressed subjects with- than without high vascular risk factors. However, I am not sure where the non-white matter hypointensity ROI covers, and it is possible to visually display the non-wm hypointensity regions in freeview?

Appreciate your guidance in advance.

Lihong

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Yes, they are typically in gray matter, although I’m not sure we see them very often (sometimes in the basal ganglia I think)

From: freesurfer-bounces@nmr.mgh.harvard.edu freesurfer-bounces@nmr.mgh.harvard.edu On Behalf Of L Sent: Friday, September 18, 2020 11:28 AM To: freesurfer@nmr.mgh.harvard.edu Subject: [Freesurfer] Fwd: non-white matter hypointensity

External Email - Use Caution Dear experts,

I am wondering what the non-white matter hypointensity refers to. Does it refer to hypointensity in subcortical regions or all brain regions except white matter? When we do data analysis using volume results from ROI tables, we found a greater volume of non-wm hypointensity in depressed subjects with- than without high vascular risk factors. However, I am not sure where the non-white matter hypointensity ROI covers, and it is possible to visually display the non-wm hypointensity regions in freeview?

Appreciate your guidance in advance.

Lihong