Dear Dawn, Thank you very much for your interest in the tool, but we do not have such a dataset, sorry! Having said that, I don’t think the alveus should make a big difference in Dice scores… Cheers, /E

Juan Eugenio Iglesias Senior research fellow CMIC (UCL), MGH (HMS) and CSAIL (MIT) http://www.jeiglesias.com

From: freesurfer-bounces@nmr.mgh.harvard.edu on behalf of "Dawn C. Matthews" dmatthews@admdx.com Reply-To: Freesurfer support list freesurfer@nmr.mgh.harvard.edu Date: Thursday, 23 January 2020 at 20:36 To: "freesurfer@nmr.mgh.harvard.edu" freesurfer@nmr.mgh.harvard.edu Subject: [Freesurfer] Hippocampal subfield validation

External Email - Use Caution Dear Freesurfer Team, Thank you for your work on the segmentation and analysis tools that have been provided through Freesurfer and that have been used so widely. We are wondering if there is a T1 image data set available for which manual delineation of the boundaries of the hippocampal subfield summation has been performed, and whether the images and masks might be available for DICE comparison to the masks and volume produced by FS in users’ hands? We note that the subfield summation does not include the alveus and therefore direct comparison to masks generated using standard manual hippocampal segmentation protocols is not straightforward. With thanks and best regards, Dawn Matthews

Dawn C. Matthews CEO, ADM Diagnostics, Inc. 555 Skokie Blvd., Suite 500 Northbrook, Illinois 60062 dmatthews@admdx.commailto:dmatthews@admdx.com