Dear Experts:

I am very new to freesurfer glmfit and this post may seem dumb. I wanted to find the correlation between Cth and Education for each of HC and RRMS group regressing out the effect of gender and (demeaned) age. My fsgd file is something like below.

GroupDescriptorFile 1 Title Group-Edu-Correlation MeasurementName thickness Class FemaleHC Class FemaleRRMS Class MaleHC Class MaleRRMS Variables Age Education Input 1 FemaleRRMS -7.97 0.243 Input 2 MaleRRMS -2.97 -1.300 Input 3 FemaleHC -12.97 -0.914 Input 5 Male HC 4.03 -1.686 ………………….. I used DODS method. For HC, I set the correlation matrix as: 0 0 0 0 0 0 0 0 0.5 0 0.5 0 And for RRMS, I set the matrix as: 0 0 0 0 0 0 0 0 0 0.5 0 0.5

1. I am wondering, if my DODS contrasts are correct. 2. To get better DOF, should I create two different FSGD file for each group (i.e. one for HC and one for RRMS)? 3. If I create two different FSGD file for each group then can I use DOSS method and use the contrast: 0 0 0 1 ?

Thanks, Anwar

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