yes, it is the same contrast

On 11/20/2023 3:30 PM, Laura Willers de Souza wrote:

External Email - Use Caution

Great, thanks so much! But I am having difficulty understanding how to construct the contrast to answer the following question "Is the interaction between group (CU/CI) and cortisol significant regressing out the effect of sex, age, APOE_carrier, abeta and ptau?" It seems like the contrast would be the same as before.. Can you help me with this?

Thanks again!

*Laura Willers de Souza *

PhD Student in Pharmacology and Therapeutics

Zimmer Lab - Federal University of Rio Grande do Sul

• Porto Alegre/RS - Brazil

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Douglas N. Greve https://secure-web.cisco.com/1yYgRLzmOCtuh8UFLaxt4ucohab6Ii9cqIDNXc9_tUgQITTp1lOWVlAhzXYGkoInMWkZJnqBum7Q2bchzciGSB2Na5ppT64MdUHXfn7DI7OxVbl4tT_fQgG0kh4IlbeSX880ZgCJICom9qj1NBstIOI_qjcTChjXuR3dPdszFYItn-gVUJfGCKXlG9o7fhLWguzZ50_ydhnvD4rOrLoYLiBMx5Nmfxu8b5Qmskd6WJN4ex-Jbo86HQs-OZhybUtFxJTLMjaMs7VA2KehPsIkWC3mSNsPAK9OmfLQGqixmeiXleO-ZWJPtFvWKnaHcn4WLC4dwagoumvUqRgC7u1xm6-Cyydvyaps-m9D_aFSH-mc/https%3A%2F%2Fwww.mail-archive.com%2Fsearch%3Fl%3Dfreesurfer%40nmr.mgh.harvard.edu%26q%3Dfrom%3A%2522Douglas%2BN.%2BGreve%2522 Wed, 15 Nov 2023 06:54:36 -0800 https://secure-web.cisco.com/1YP7c0yUfORmuLGAmHVodnKa9al2_Y0u_TMgwZ8HHpNLBopCps66WL5fi8BIQOtGT2EIe686Cb-kKvvGhRCe4_SaK0WJ3KOn4c9Sj2WdQqojkvfBeHT3N0kEtpp4XZYzhlfT_eJ5jkScsByN1WqEs3tHZcGwdZjDYiA2VHhgtKgDSnuHH09-N9wy-MRx6r58e_5aLN4OM9T2RKO6OnJ5mx8nK9pUHOSr26E4tD08yymXHHwjtsv4xTNRM0PO-47K6TZb26i11we8tVt1lnats3dUctrHhexXc9YvBQKMu_pUzZw2Ma-p89k7jGVEZBbCbg5alwGGg9GzThW3Fv1_YxTcKTYDjh20IrtgY3QjPvlU/https%3A%2F%2Fwww.mail-archive.com%2Fsearch%3Fl%3Dfreesurfer%40nmr.mgh.harvard.edu%26q%3Ddate%3A20231115

Yes, that looks right (assuming that cortisol is your first variable) ---- On 11/7/2023 3:49 PM, Laura Willers de Souza wrote:         External Email - Use Caution Hello FreeSurfer Developers, Following the FSGD examples on the website, I built the following test: Question: Is there an association between cortisol and cortical thickness regressing out the effect of sex, age, APOE4_carrier (1=1 or 2 alleles, 0=no alleles), abeta, ptau, diagnosis (CU and CI)? Regressors: 2 factors (sex, diagnosis) with 2 levels each, 5 covariates (age, APOE4_carrier (1=1 or 2 alleles, 0=no alleles), abeta, ptau, cortisol) >> 24 regressors Contrast: 0 0 0 0 0.5 -0.5 0.5 -0.5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 FSGD: GroupDescriptorFile 1 Title CSF_semgrupos Class MaleCU Class MaleCI Class FemaleCU Class FemaleCI Variables Cortisol Age ABETA ptau APOE4_carrier Input 098_S_4003_I224603 MaleCI 11 81.3 741.5 22.83 1 Does this feel right to you? I am having difficulty understanding how to construct the contrast to answer the following question "Is the interaction between group (CU/CI) and cortisol significant regressing out the effect of sex, age, APOE_carrier, abeta and ptau?" It seems like the contrast would be the same as before.. Can you guys help me with this? Thanks in advance! *Laura Willers de Souza * PhD Student in Pharmacology and Therapeutics Zimmer Lab - Federal University of Rio Grande do Sul - Porto Alegre/RS - Brazil

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