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Thank you for that Rafa. We'd be using FS for different analyses (diffusion, PET, etc.), but from what I gather this may affect volumetric data the most due to the increased accuracy in 7.4 segmentation. Does that sound accurate? I am currently sifting through the literature, but would love some input from the group.

Lisa ________________________________ From: Rafael Navarro rafa.navarrogo@gmail.com Sent: Thursday, August 28, 2025 11:14 AM To: Freesurfer support list freesurfer@nmr.mgh.harvard.edu Subject: [Freesurfer] Re: Version 7.2 & 7.4

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Hi Lisa,

I think it depends on your ultimate goal and how much version differences might affect your experiments. There is some literature suggesting that mixing FreeSurfer versions can improve generalisation for ML models (see: https://secure-web.cisco.com/1EhtTqY94KKIGZ7faBSR_uVB8wAcatIaSfjBVo5Ri7F3nWq...https://secure-web.cisco.com/1RN3RfqYWfdfSr9TwJ7cGeVCNvbsJ4j7NGNqg7lGZx0TxMmmCDVnVyZlQR9QiwXsxfB3UVAakwDlH-TSzc47gMiZjrYnwpOjVu2zItZt94oQkqOJJ5fSDItuiHNPJQbSKwldRFN8JoZTkeRANVcLuyZjy7Vq1LASTytI64fJ-5UmNbVuajpYoeRGm2TtGjcKoG6qn7SyvvHo_Hh32BTcvONSd79z8K1uYmR2ASiDjems0EEUWdGBu0HxM3p28JD7z8OVlA1BCG732-PDm3cnh1A11UYR_ZxHrWOuBK69ats5U6WhxMeMoNr-N7hcWInFO6pOnJ7HFGiYZe1Ylwx9YTQ/https%3A%2F%2Furldefense.com%2Fv3%2F__https%3A%2F%2Fsecure-web.cisco.com%2F1wClK6CC9AAiFpgEXK31JJZpR9E41aW_F5ULr2oX_iGYG8nBR4OQW2ZYdEzd5vmFeMldh3ws3fYSgGhms1mCeotcHFuibW3m9GGG-Gq9aRgz1PYMfLbXdCMpeRIjxiEInmnXZYRX4ZEv-i2dWCnkXC7GM6grqoV06S2dlIgYDslyu_tmwXWx-qTScEh8lQi8F-Vxtpq53S5f7baM5S3lu0P7oyBptdpFXHVsOCGw5553HyiyKXJ7T7pDeqY55akQ7fj1EJvXc1cYMai1aNNnBiITtM893WW8oSU8DzZX566WP0VW8zad8kAoS8yPZwSizWnCaHPPBukuSNPk7Ybo0eg%2Fhttps*3A*2F*2Fdoi.org*2F10.1016*2Fj.ynirp.2024.100214*3Futm_source*3Dchatgpt.com__;JSUlJSUlJQ!!OLgoXmg!WldY8fG9c9xBJrAmNRfNN7YXSn16s00FKHq0BoF7HBKE3gJQ2tJV0ynH1R1P4IEN_gAG1C0ReqWUoCeR-gemX-AuBUs$).

That said, I’m not an expert in this area, so please take this as a pointer rather than firm advice.

Best, Rafa

El jue, 28 ago 2025 a las 20:06, Taylor, Lisa (<ltaylor2@hs.uci.edumailto:ltaylor2@hs.uci.edu>) escribió:

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Hi group,

I was curious if using both versions of freesurfer 7.2 & 74 would be acceptable? We realized some of our data contained both due to some miscommunication.

Would the recommendation be to use just one 7.X version, or are the two similar enough to use concurrently?

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