Do you mean the difference between the d,m,h classes? If so, it would be 1 1 -1 -1 0 0 (rest all 0s) 1 1  0  0 -1 -1 ... 0 0 1 1 -1 -1 ...

On 4/14/2022 9:50 AM, David wrote:

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Hi Freesurfer experts,

I'm very sorry to bother you, but I am very confused with the     following questions:

My experimental design includes two discrete factors:     with three levels (d,m,h); gender (f, m), and two Nvariables

So I can get 6 classes: df, dm,mf, mm,hf,hm.

I want to perform the difference between any of the classes     leves analysis with regressing out the effect of gender and two     Nvariables, but I don't know the rules for setting the contrasts for     the F-test.  The contrast matrix I used is:

1 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0     0 0 0 1 -1 0 0 0 0 0 0 0 0 0 0 0 0 0     1 0 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0     0 0 0 1 0 -1 0 0 0 0 0 0 0 0 0 0 0 0     My orders are as follows：     mris_preproc --fsgd glmteach.fsgd --target fsaverage --hemi lh --meas area --out lh_teach.mgh     mris_preproc --fsgd glmteach.fsgd --target fsaverage --hemi rh --meas area --out rh_teach.mgh

mri_glmdir --y lh_teach.mgh --fsgd glmteach.fsgd --C glmteach.mtx --glmdir group.area_sm.lh --fwhm 10 --surface fsaverage lh --eres-save

mri_glmdir --y rh_teach.mgh --fsgd glmteach.fsgd --C glmteach.mtx --glmdir group.area_sm.rh --fwhm 10 --surface fsaverage rh --eres-save

mri_glmdir-sim --glmdir group.area_sm.lh --2spaces --cwp 0.05 --perm 100 1.3 abs     mri_glmdir-sim --glmdir group.area_sm.rh --2spaces --cwp 0.05 --perm 100 1.3 abs

But there is no region of interest after running，        Can I change the correction method or did I use it wrong

Any help will be very appreciated.

Best wishes,

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