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They just described this regarding the ICC in their methods section: "For the present study, intrinsic cortical curvature was calculated using Gaussian curvature calculations in the following regions of interest from both the left (LH) and right (RH) hemispheres: the caudal anterior cingulate cortex (henceforth “ACC”), the rostral middle frontal cortex (henceforth “DLPFC”), the superior parietal region (henceforth “parietal cortex”), and the superior temporal region (henceforth “temporal cortex”). The regions of ICC quantification were chosen from their delineation atlas, the Desikan-Killiany cortical atlas (Desikan et al., 2006), for their approximation to regions of observed glutamatergic dysregulation (Iwata et al., 2019; Shah et al., 2020b) and structural decline (Anderson et al., 2015; Bodnar et al., 2010; Fan et al., 2023; Wannan et al., 2019) in available literature."

Thanks, Vittal

On Wed, Jul 23, 2025 at 3:50 PM freesurfer-request@nmr.mgh.harvard.edu wrote:

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Today's Topics:

1. Inquiry Regarding Intrinsic Cortical Curvature (ICC) Calculation in

FreeSurfer (vittal korann) 2. Re: Inquiry Regarding Intrinsic Cortical Curvature (ICC) Calculation in FreeSurfer (Fischl, Bruce R.,PHD)

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Message: 1 Date: Wed, 23 Jul 2025 15:44:14 -0400 From: vittal korann vittalkorann@gmail.com Subject: [Freesurfer] Inquiry Regarding Intrinsic Cortical Curvature (ICC) Calculation in FreeSurfer To: Freesurfer support list freesurfer@nmr.mgh.harvard.edu Message-ID: <CACyMoT3Vps-CC9G= mFeHvNJJCh9LfhSVbVNskAwfi8H-6np7ow@mail.gmail.com> Content-Type: multipart/alternative; boundary="000000000000b91b68063a9def84"

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Dear FreeSurfer Team,

I’m currently working on a project involving cortical morphology and am particularly interested in calculating Intrinsic Cortical Curvature (ICC) using FreeSurfer.

I came across a recent publication (

https://secure-web.cisco.com/1oL8IZPRfQ5o5UDqVHfF8rU4SLPTHeXEdS4OHOftgKkxaXn...) that utilized ICC in their statistical analysis. I’d like to clarify a couple of points regarding how ICC is derived within the FreeSurfer framework:

1. Is Gaussian curvature as computed by FreeSurfer considered equivalent to

ICC?

2. If not, are there additional steps or specific tools required to compute

ICC beyond the standard curvature outputs (e.g., via mris_curvature or mris_curvature_stats)?

Any guidance or documentation you could share would be greatly appreciated. I’m aiming to ensure methodological consistency with published work and would be grateful for your insights.

Thank you for your time and support.

With regards, Vittal