Hi Freesurfer, I'm currently making a structural analysis on about 60 Parkinson's Disease patients using freesurfer - and i would like to make a ROI analysis. I have two MR pictures of each subject; a picture where the patients are on medication and an off medication picture (the medication is levodopa: Precursor to catecholamines e.g. dopamin). I would like to investigate the morphological differences in specific areas of the brain such as Nucleus Accumbens bilat., Orbitofrontal cortex bilat. and Anterior Cingulate Cortex. How would you consider freesurfer's strength in investigating differences in such specific areas in the brain? I have another question regarding movement artefacts. In a structural analysis would you remove pictures with movement artefacts if the segmentation after manual editing seems alright? Best,Silas
Hi Silas
I'll leave the movement question for Martin Reuter who has been investigating this extensively.
For your other question, one of the central focuses of our recent research has been in improving the sensitivity and reliability of longiudinal analyses like these, so it is definitely a major strength of ours.
cheers Bruce
On Fri, 25 Jul 2014, Silas wrote:
Hi Freesurfer, I'm currently making a structural analysis on about 60 Parkinson's Disease patients using freesurfer - and i would like to make a ROI analysis. I have two MR pictures of each subject; a picture where the patients are on medication and an off medication picture (the medication is levodopa: Precursor to catecholamines e.g. dopamin). I would like to investigate the morphological differences in specific areas of the brain such as Nucleus Accumbens bilat., Orbitofrontal cortex bilat. and Anterior Cingulate Cortex. How would you consider freesurfer's strength in investigating differences in such specific areas in the brain?
I have another question regarding movement artefacts. In a structural analysis would you remove pictures with movement artefacts if the segmentation after manual editing seems alright?
Best, Silas
Hi Bruce, Thanks for your help! But - would you recommend a longitudinal analysis even though i have quite many movement artefacts and bad scans - instead of just avoid using the worst picture? At the moment I'm making a cross-sectional study. I would also like to make an investigation of OFC grey matter thickness in the two groups; on and off medication (using freesurfer). Is Martin Reuther on vacation at the moment? Best, Silas
Date: Fri, 25 Jul 2014 09:45:16 -0400 From: fischl@nmr.mgh.harvard.edu To: freesurfer@nmr.mgh.harvard.edu Subject: Re: [Freesurfer] Freesurfer ROI analysis
Hi Silas
I'll leave the movement question for Martin Reuter who has been investigating this extensively.
For your other question, one of the central focuses of our recent research has been in improving the sensitivity and reliability of longiudinal analyses like these, so it is definitely a major strength of ours.
cheers Bruce
On Fri, 25 Jul 2014, Silas wrote:
Hi Freesurfer, I'm currently making a structural analysis on about 60 Parkinson's Disease patients using freesurfer - and i would like to make a ROI analysis. I have two MR pictures of each subject; a picture where the patients are on medication and an off medication picture (the medication is levodopa: Precursor to catecholamines e.g. dopamin). I would like to investigate the morphological differences in specific areas of the brain such as Nucleus Accumbens bilat., Orbitofrontal cortex bilat. and Anterior Cingulate Cortex. How would you consider freesurfer's strength in investigating differences in such specific areas in the brain?
I have another question regarding movement artefacts. In a structural analysis would you remove pictures with movement artefacts if the segmentation after manual editing seems alright?
Best, Silas
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The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
Hi Silas
are the two scans at the same time point? It really depends what your hypothesis is. Certainly start with a cross-sectional analysis, as you need to anyway. And yes, you are correct - it is usually better to pick the better scan than use both if one of them is corrupted
cheers Bruce
On Mon, 28 Jul 2014, Silas wrote:
Hi Bruce, Thanks for your help!
But - would you recommend a longitudinal analysis even though i have quite many movement artefacts and bad scans - instead of just avoid using the worst picture? At the moment I'm making a cross-sectional study. I would also like to make an investigation of OFC grey matter thickness in the two groups; on and off medication (using freesurfer).
Is Martin Reuther on vacation at the moment?
Best, Silas
Date: Fri, 25 Jul 2014 09:45:16 -0400 From: fischl@nmr.mgh.harvard.edu To: freesurfer@nmr.mgh.harvard.edu Subject: Re: [Freesurfer] Freesurfer ROI analysis
Hi Silas
I'll leave the movement question for Martin Reuter who has been investigating this extensively.
For your other question, one of the central focuses of our recent research has been in improving the sensitivity and reliability of longiudinal analyses like these, so it is definitely a major strength of ours.
cheers Bruce
On Fri, 25 Jul 2014, Silas wrote:
Hi Freesurfer, I'm currently making a structural analysis on about 60 Parkinson's Disease patients using freesurfer - and i would like to make a ROI analysis. I hav
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two MR pictures of each subject; a picture where the patients are on medication and an off medication picture (the medication is levodopa: Precursor to catecholamines e.g. dopamin). I would like to investigate the morphological differences in specific areas of the brain such as Nucleus Accumbens bilat., Orbitofrontal cortex bilat. and Anterior Cingulate Corte
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How would you consider freesurfer's strength in investigating differences
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such specific areas in the brain?
I have another question regarding movement artefacts. In a structural analysis would you remove pictures with movement artefacts if the segmentation after manual editing seems alright?
Best, Silas
_______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
freesurfer@nmr.mgh.harvard.edu
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Silas