Hello All,

We are trying to obtain an accurate measurement of the total WM volume (cerebral WM + WM hypointensities) in a group of patients with multiple sclerosis (MS).

As per Bruce's suggestion, we are now using mris_wm_volume that gives more accurate measures than aseg.stats.

When looking at our data we have noticed that within the WM surface (yellow line) there are many voxels labeled as Cerebral-Cortex (mainly in places where we put cp to expand the WM surface), and some others labeled as None (mainly in places of iuxtacortical MS lesions).

As expected basing on how mris_wm_volume works, we have noticed that WM volume actually change upon manual editing of these mislabeled voxels in the aseg.mgz (i.e. relabeling them as actual WM).

Thus, we were wondering if there is any way to capture and correct for all these mislabeled voxels in a more automated manner (i.e. automatically considering Cerebral-Cortex and None voxels included in the WM surface as actual WM in the mris_wm_volume computation).

In this way it should be possible to get more accurate measures of WM volumes as well as save a lot of time in manual editing.

Thanks a lot in advance,

Antonio

Antonio Gallo, MD

NIB-NINDS-NIH

10 Center Drive

Building 10, Room 5C203B

Bethesda, MD, 20892 - USA

ph #: 001-301-496.7368

fax #: 001-301-402.0373

***********************