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Do any of these examples https://secure-web.cisco.com/1xXCaIIxRlmFmiJuTJbxdJBVn9Mf-MoaaUpeIjtXwUbA2uU... generalize to your case? In particular, look at *Two Groups (One Factor/Two Levels), One Covariate* Yours would be one factor/three levels. what do you mean by the group effect? Do you mean that you expect different offsets for each group but the same thickness-score slope across groups? If yes, then use DOSS. If you expect different slopes for the groups, do  you want to test for a difference in slopes across groups or do you just want to test whether the mean slope is different than 0?

On 8/14/2023 2:17 PM, Finn, Quentin wrote:

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Freesurfer experts,

I have some surface data (say thickness) that I'd like to correlate with a neuropsyche measure (so one value per subject, a continuous variable)

This is complicated, though, by the presence of a (discrete) covariate that splits my cohort up into three groups (for ease of explanation, say the groups are: young, middle, old).

I'm hoping to use mri_glmfit to see where the neuropsyche is a significant predictor of thickness while controlling for the group effect, but I'm struggling to set up the contrast / fsgd matrix

Is there a way to accomplish this in mri_glmfit?

thanks so much for your help!

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