Hi Karishma

The Matlab LME toolbox is only intended for univariate and mass-univariate analyses and not for multivariate analysis. However the recently developed spatiotemporal model can be modified to work with multivariate data (instead of regions of voxels there will be multiple variables and join F-tests) as long as a parametric correlation matrix among the variables and its first derivative is provided. This is straightforward for two-variable multivariate data as there is only one correlation parameter.

In any case this is not directly implemented there and would require some effort and statistical-algebra expertise to put it together.

Best -Jorge

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De: Karishma Smart karishma.l.smart@gmail.com Para: freesurfer@nmr.mgh.harvard.edu Enviado: Lunes 29 de septiembre de 2014 10:17 Asunto: [Freesurfer] LME Models

Dear Freesurfers,

This is a repeat question as either I did not see the response to the intial query (I apologise in that case!) or it was never answered. I am planning to do a longitudinal analysis. After I have processed the data through a longitudinal stream, should I use the LME model? I understand it is the most highly recommended for a comprehensive analysis; however the Freesurfer webpage says it is for univariate and mass-univariate analyses only. I would like to do a multivariate analysis. Can I still use the Matlab LME model? If not, is there an alternative way to do this? Any help would be appreciated!

Thanks! Karishma

-- Karishma Smart B.A. Biological Sciences Cornell University Class of 2013 Boston University School of Graduate Medical Sciences Class of 2015 _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

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