Hi Mercedes

you probably want to retain the information that you have more than one control subject as opposed to simply averaging them and treating the average as a single subject. While you can create a new average, it isn't necessary to do so. You can just keep track of all the control areas/volumes/thicknesses and compare them in the existing coordinates.

cheers Bruce

On Thu, 22 Nov 2018, m s wrote:

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Hi,I am looking forward to create a normal database for daily use to compare with individual patient mr volumes. I was thinking about creating an average subject from a normal database of multiple subjects. After I have my average subject, would it be posssible and correct to compare this average recon individually to a new subjects recon, redoing all the averaging and comparing process only between this two?  Thank you Mercedes