Hi Gonzalo,

of course.

There is even a difference when running the same FS version with a different operating system (due to differences in the numerical libraries, optimizations etc).

Are changes big or small? In a single case they can be very big (it could be a case that failed in 5.3 and works with 6.0 - or the other way)

Are changes directional (significantly larger or smaller volumes/thickness)? Hard to say and hard to detect if small, but it can happen due to a new algorithm that measurements are consistently larger (/smaller) than in another version. We try to avoid this, but it can theoretically happen.

That is why it is so important to stick with the same version and operating system when processing data.

Best, Martin

On 11/10/2015 04:48 PM, Gonzalo Rojas Costa wrote:

Hi:

There are any difference between subcortical structures volume, cortical thickness, supratentorial volume, gray matter volume, etc. computed with freesurfer 5.3 and 6.0 ?...

Sincerely,

Gonzalo Rojas Costa